阿塞丙嗪
別名: PromAce, Aceproject, Aceprotabs, Plegicil, Notensil, Atravet, Acecare, ACP
藥物類別: Phenothiazine Sedative/Tranquilizer
* **尿液變色：** 此藥物可能會使您寵物的尿液暫時變成粉紅色或紅棕色；這是正常的副作用，無需驚慌。 * **非止痛藥：** 阿塞丙嗪能提供鎮靜效果，但**不能止痛**。如果您的寵物正在接受會引起疼痛的處置，將需要其他藥物。 * **保持環境安靜：** 即使您的寵物看起來很睏，牠們仍可能被巨大的噪音或突然的動作嚇到，並可能做出不可預測的反應。在藥效消退期間，請讓牠們待在安靜、平靜的環境中。 * **第三眼瞼：** 您可能會注意到寵物的「第三眼瞼」（眼內角的薄膜）覆蓋了部分眼睛。這是正常現象，會隨著藥效消退而恢復。 * **法規：** FDA 批准用於非食用目的之犬、貓和馬匹。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Sedation
- Sedation
- Labeled dose
- Restraint/sedation
- Preanesthetic
- To reduce anxiety in the painful patient (not a substitute for analgesia)
- Premedication
- As a premedicant with morphine
- Sedation and premedication (Non-Boxers)
- Sedation and premedication (Non-Boxers)
- Sedation and premedication (Non-Boxers)
- Sedation and premedication (Boxers)
- As a tranquilizer
- Sedation
- Labeled dose
- To reduce anxiety in the painful patient (not a substitute for analgesia)
- Restraint/sedation
- Premedication prior to ketamine
- Sedation and premedication
- Sedation and premedication
- Sedation and premedication
- Sedation
- Sedation
- Sedative one hour prior to local anesthesia
- Sedation
- Sedation
- For brief periods of immobilization
- Labeled dose
- For mild sedation
- As a preanesthetic
- Neuroleptanalgesia
- For adjunctive treatment of laminitis (developmental phase)
- Rabbits: As a tranquilizer
- Rabbits: As a premed
- Mice, Rats, Hamsters, Guinea pigs, Chinchillas
給藥方式
POIVIMSC
可能的副作用
- Hypotension and cardiovascular collapse
- Bradycardia (vagally mediated) or reflex tachycardia
- Hypothermia or hyperthermia
- Penile protrusion/prolapse in large animals (especially stallions)
- Prolapse of the membrana nictitans (third eyelid)
- Decreased tear production (especially in cats)
- Paradoxical excitement, restlessness, or aggression
- Transient pain at IM injection sites
- Decreased hematocrit (due to splenic sequestration of RBCs)
注意事項與禁忌
- Significant cardiac disease
- Hypovolemia, hypotension, or shock
- Tetanus or strychnine intoxication
- Intra-arterial injection in horses (can cause severe CNS excitement, seizures, death)
- Use with extreme caution in very young, geriatric, or debilitated animals
- Avoid in racing animals within 4 days of a race
- **Dosage Adjustments:** The manufacturer's labeled dose is often considered up to 10 times higher than clinically necessary. Use lower end of dose ranges. **Breed Sensitivities:** * **MDR1 Mutation:** Dogs with the MDR1 (ABCB1) mutation (Collies, Australian Shepherds, etc.) require a 25% dose reduction if heterozygous, and a 30-50% reduction if homozygous. * **Giant Breeds & Sight Hounds:** Extremely sensitive; require lower doses. * **Terriers:** May be somewhat resistant to effects. **Administration:** Give IV injections slowly. Allow at least 15 minutes for onset of action. **Never inject intra-arterially** in horses. **Behavioral:** Use cautiously as a restraining agent in aggressive dogs; it may make the animal more prone to startle and react to noises. **Other:** May cause regurgitation of ruminal contents in cattle during general anesthesia induction.
藥物相互作用
- Acetaminophen: Possible increased risk for hypothermia
- Antacids: May cause reduced GI absorption of oral phenothiazines
- Antidiarrheal mixtures (Kaolin/pectin, bismuth): May cause reduced GI absorption of oral phenothiazines
- CNS Depressant Agents (barbiturates, narcotics, anesthetics): May cause additive CNS depression if used with acepromazine
- Dopamine: Acepromazine may impair the vasopressive action of dopamine
- Emetics: Acepromazine may reduce the effectiveness of emetics
- Epinephrine, Ephedrine: Concomitant use can lead to unopposed beta-activity causing vasodilation and increased cardiac rate (epinephrine reversal)
- Metoclopramide: May increase risks for extrapyramidal adverse effects
- Opiates: May enhance hypotensive effects; dosages of acepromazine are generally reduced when used with an opiate
- Organophosphate Agents: Effects may be potentiated; do not give within one month of worming with these agents
- Phenytoin: Metabolism may be decreased if given concurrently
- Procaine: Activity may be enhanced by phenothiazines
- Propranolol: Increased blood levels of both drugs may result
- Quinidine: May cause additive cardiac depression
- CNS depressants (barbiturates, propofol, alfaxalone, volatile anaesthetics): Additive CNS depression; doses of other anaesthetic drugs should be reduced when ACP is used for premedication
- Adrenaline (Epinephrine): Unopposed beta activity causing severe vasodilation and tachycardia (due to ACP's alpha-adrenergic blockade)
- Antidiarrhoeals (kaolin/pectin, bismuth salicylate) and Antacids: Reduced GI absorption of oral phenothiazines
常見問題
阿塞丙嗪用於寵物有什麼用途？
• 尿液變色： 此藥物可能會使您寵物的尿液暫時變成粉紅色或紅棕色；這是正常的副作用，無需驚慌。 • 非止痛藥： 阿塞丙嗪能提供鎮靜效果，但不能止痛。如果您的寵物正在接受會引起疼痛的處置，將需要其他藥物。 • 保持環境安靜： 即使您的寵物看起來很睏，牠們仍可能被巨大的噪音或突然的動作嚇到，並可能做出不可預測的反應。在藥效消退期間，請讓牠們待在安靜、平靜的環境中。 • 第三眼瞼： 您可能會注意到寵物的「第三眼瞼」（眼內角的薄膜）覆蓋了部分眼睛。這是正常現象，會隨著藥效消退而恢復。 • 法規： FDA 批准用於非食用目的之犬、貓和馬匹。
阿塞丙嗪對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。