Toceranib
別名: Palladia
> **Important Safety Warning:** Toceranib is an anti-cancer drug. **Always wear gloves** when handling the tablets or cleaning up your pet's feces, urine, or vomit. Pregnant women or children should not handle this medication. * **Administration:** May be given with or without food. **Do not split or crush the tablets.** * **Adverse Effects:** Watch closely for side effects. **Stop the medication immediately and contact your veterinarian** if your dog develops severe diarrhea (4 or more watery stools a day), loss of appetite, vomiting, or any signs of bleeding in the stool (red blood or dark, tarry stools). * **Missed Doses:** If you miss a dose, do not double up. Give the next dose at the regularly scheduled time. * Always read the Client Information Sheet provided with your prescription.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Malignancies (Off-label)
- Patnaik grade II or III, recurrent, cutaneous mast cell tumors (Label Dose)
- Patnaik grade II or III, recurrent, cutaneous mast cell tumors (Clinical Experience Dose)
- Mast cell tumours and other malignancies
給藥方式
可能的副作用
- Diarrhea (can be severe)
- Decreased or loss of appetite
- Lameness
- Weight loss
- Gastrointestinal bleeding (blood in stool, melena)
- Muscle cramping
- Neutropenia
- Hypoalbuminemia
- Thromboembolic disease (including pulmonary emboli)
- Vasculitis
- Pancreatitis
- Nasal depigmentation
- Change in coat or skin color
- Epistaxis
注意事項與禁忌
- Breeding, pregnant, or lactating bitches
- Dogs less than 24 months of age or weighing less than 5 kg (safe use not evaluated)
- Pregnant or lactating bitches
- Dogs < 2 years old
- Dogs < 5 kg
- Patients with any signs of gastrointestinal haemorrhage
- Known hypersensitivity to toceranib
- **Surgical Warning:** Because toceranib can cause vascular dysfunction leading to edema and thromboembolism, **wait at least 3 days** after stopping the drug before performing surgery. **Systemic Mastocytosis:** When used in the presence of systemic mast cell tumors, significant mast cell degranulation may occur, leading to severe adverse effects (e.g., anaphylaxis, GI ulceration). Attempt to rule out systemic mastocytosis prior to starting therapy. **Hazardous Drug Handling:** Use caution when handling this medication. Wear gloves and follow standard veterinary cytotoxic drug handling protocols. **Toxicity Mimicry:** Toceranib can cause clinical signs similar to those seen with aggressive mast cell tumors; if these occur, stop the drug and re-evaluate the patient.
藥物相互作用
- NSAIDs (e.g., piroxicam, carprofen): Increased risk of gastrointestinal ulceration or perforation. Use with extreme caution; never give on the same day as toceranib to avoid exacerbating GI toxicity.
- CYP3A4 Inhibitors (e.g., ketoconazole, fluconazole, itraconazole, clarithromycin, verapamil, grapefruit juice): May theoretically increase toceranib plasma concentrations and toxicity. Use with caution.
- Corticosteroids: Increased risk of severe gastrointestinal toxicity and ulceration.
- NSAIDs: Increased risk of severe gastrointestinal toxicity and ulceration.
- Other chemotherapeutic agents: Potential for additive myelosuppression and systemic toxicity. Use with caution.
常見問題
Toceranib用於寵物有甚麼用途？
> **Important Safety Warning:** Toceranib is an anti-cancer drug. **Always wear gloves** when handling the tablets or cleaning up your pet's feces, urine, or vomit. Pregnant women or children should not handle this medication. * **Administration:** May be given with or without food. **Do not split or crush the tablets.** * **Adverse Effects:** Watch closely for side effects. **Stop the medication immediately and contact your veterinarian** if your dog develops severe diarrhea (4 or more watery stools a day), loss of appetite, vomiting, or any signs of bleeding in the stool (red blood or dark, tarry stools). * **Missed Doses:** If you miss a dose, do not double up. Give the next dose at the regularly scheduled time. * Always read the Client Information Sheet provided with your prescription.
Toceranib對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。