Tinidazole
別名: Tindamax, Estovyn-T, Fasigyn, Tiniba, Tiniameb, Tinidazol
* **Administration**: Give this medication with food to reduce stomach upset. * **Taste Warning**: This medication is extremely bitter. Do not crush or break tablets unless instructed by your veterinarian, as the bad taste may cause your pet to drool excessively or refuse to eat. * **Alcohol Avoidance**: Ensure your pet does not have access to any products containing alcohol while on this medication. * **When to Call the Vet**: Contact your veterinarian if gastrointestinal signs (vomiting, lack of appetite, diarrhea) are severe or persist. * **Emergency Signs**: Contact your veterinarian **immediately** if your pet shows signs of behavior changes, eyes darting back and forth (nystagmus), convulsions/seizures, or difficulty walking/climbing stairs (ataxia). These can be signs of drug toxicity.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Stomatitis, anaerobic infections
- Tritrichomonas foetus (experimental)
- Susceptible anaerobic infections
- Stomatitis, anaerobic infections
- Giardiasis
給藥方式
可能的副作用
- Vomiting
- Inappetence
- Diarrhea
- Neurotoxicity (ataxia, nystagmus, seizures)
- Hypersalivation (due to bitter taste)
注意事項與禁忌
- Hypersensitivity to tinidazole or other 5-nitroimidazoles (e.g., metronidazole, ronidazole)
- Food-producing animals (prohibited use)
- Use with caution in patients with **hepatic dysfunction**, as the drug is metabolized by the liver. Use with extreme caution in animals susceptible to **seizures** or with pre-existing neurological disease, as 5-nitroimidazoles can cross the blood-brain barrier and cause neurotoxicity. **Black Box Warning (Human Label)**: Carcinogenicity has been seen in mice and rats treated chronically with metronidazole. Avoid unnecessary use and reserve for indicated conditions. **Reproductive/Nursing**: Decreased fertility noted in male rats. Crosses the placenta (mutagenic potential; avoid in first trimester; FDA Category C). Distributed into maternal milk; use milk replacer if treating a nursing dam.
藥物相互作用
- Alcohol: May induce a disulfiram-like reaction (nausea, vomiting, cramps).
- Cimetidine: May decrease the metabolism of tinidazole and increase the likelihood of dose-related side effects.
- Ketoconazole: May decrease the metabolism of tinidazole and increase the likelihood of dose-related side effects.
- Cyclosporine: Tinidazole may increase the serum levels of cyclosporine.
- Tacrolimus (systemic): Tinidazole may increase the serum levels of tacrolimus.
- Fluorouracil (systemic): Tinidazole may increase the serum levels of fluorouracil and increase the risk of toxicity.
- Lithium: Tinidazole may increase lithium serum levels and increase the risk for lithium toxicity.
- Oxytetracycline: May antagonize the therapeutic effects of metronidazole (and presumably tinidazole).
- Phenobarbital: May increase the metabolism of tinidazole thereby decreasing blood levels.
- Rifampin: May increase the metabolism of tinidazole thereby decreasing blood levels.
常見問題
Tinidazole用於寵物有甚麼用途？
* **Administration**: Give this medication with food to reduce stomach upset. * **Taste Warning**: This medication is extremely bitter. Do not crush or break tablets unless instructed by your veterinarian, as the bad taste may cause your pet to drool excessively or refuse to eat. * **Alcohol Avoidance**: Ensure your pet does not have access to any products containing alcohol while on this medication. * **When to Call the Vet**: Contact your veterinarian if gastrointestinal signs (vomiting, lack of appetite, diarrhea) are severe or persist. * **Emergency Signs**: Contact your veterinarian **immediately** if your pet shows signs of behavior changes, eyes darting back and forth (nystagmus), convulsions/seizures, or difficulty walking/climbing stairs (ataxia). These can be signs of drug toxicity.
Tinidazole對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。