替硝唑
別名: Tindamax, Estovyn-T, Fasigyn, Tiniba, Tiniameb, Tinidazol
藥物類別: Nitroimidazole Antiprotozoal / Antibiotic
* **給藥方式**：請將此藥物與食物一起餵食，以減少腸胃不適。 * **味道警告**：此藥物非常苦。除非獸醫師指示，否則請勿壓碎或剝半藥片，因為苦味可能會導致您的寵物過度流口水或拒絕進食。 * **避免酒精**：在服用此藥物期間，請確保您的寵物不會接觸到任何含有酒精的產品。 * **何時聯繫獸醫**：如果腸胃道症狀（嘔吐、食慾不振、腹瀉）嚴重或持續存在，請聯繫您的獸醫師。 * **緊急症狀**：如果您的寵物出現行為改變、眼球快速來回轉動（眼球震顫）、抽搐/癲癇，或行走/爬樓梯困難（共濟失調），請**立即**聯繫獸醫師。這些可能是藥物中毒的跡象。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Stomatitis, anaerobic infections
- Tritrichomonas foetus (experimental)
- Susceptible anaerobic infections
- Stomatitis, anaerobic infections
- Giardiasis
給藥方式
PO
可能的副作用
- Vomiting
- Inappetence
- Diarrhea
- Neurotoxicity (ataxia, nystagmus, seizures)
- Hypersalivation (due to bitter taste)
注意事項與禁忌
- Hypersensitivity to tinidazole or other 5-nitroimidazoles (e.g., metronidazole, ronidazole)
- Food-producing animals (prohibited use)
- Use with caution in patients with **hepatic dysfunction**, as the drug is metabolized by the liver. Use with extreme caution in animals susceptible to **seizures** or with pre-existing neurological disease, as 5-nitroimidazoles can cross the blood-brain barrier and cause neurotoxicity. **Black Box Warning (Human Label)**: Carcinogenicity has been seen in mice and rats treated chronically with metronidazole. Avoid unnecessary use and reserve for indicated conditions. **Reproductive/Nursing**: Decreased fertility noted in male rats. Crosses the placenta (mutagenic potential; avoid in first trimester; FDA Category C). Distributed into maternal milk; use milk replacer if treating a nursing dam.
藥物相互作用
- Alcohol: May induce a disulfiram-like reaction (nausea, vomiting, cramps).
- Cimetidine: May decrease the metabolism of tinidazole and increase the likelihood of dose-related side effects.
- Ketoconazole: May decrease the metabolism of tinidazole and increase the likelihood of dose-related side effects.
- Cyclosporine: Tinidazole may increase the serum levels of cyclosporine.
- Tacrolimus (systemic): Tinidazole may increase the serum levels of tacrolimus.
- Fluorouracil (systemic): Tinidazole may increase the serum levels of fluorouracil and increase the risk of toxicity.
- Lithium: Tinidazole may increase lithium serum levels and increase the risk for lithium toxicity.
- Oxytetracycline: May antagonize the therapeutic effects of metronidazole (and presumably tinidazole).
- Phenobarbital: May increase the metabolism of tinidazole thereby decreasing blood levels.
- Rifampin: May increase the metabolism of tinidazole thereby decreasing blood levels.
常見問題
替硝唑用於寵物有什麼用途？
* **給藥方式**：請將此藥物與食物一起餵食，以減少腸胃不適。 * **味道警告**：此藥物非常苦。除非獸醫師指示，否則請勿壓碎或剝半藥片，因為苦味可能會導致您的寵物過度流口水或拒絕進食。 * **避免酒精**：在服用此藥物期間，請確保您的寵物不會接觸到任何含有酒精的產品。 * **何時聯繫獸醫**：如果腸胃道症狀（嘔吐、食慾不振、腹瀉）嚴重或持續存在，請聯繫您的獸醫師。 * **緊急症狀**：如果您的寵物出現行為改變、眼球快速來回轉動（眼球震顫）、抽搐/癲癇，或行走/爬樓梯困難（共濟失調），請**立即**聯繫獸醫師。這些可能是藥物中毒的跡象。
替硝唑對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。