Terbinafine
別名: Lamisil, Terbinex, Alamil, Daskil, Daskyl, DesenexMax, Finex, Maditez, Micosil, Terekol, Osurnia
### Important Information for Pet Owners * **Administration:** It is highly recommended to **give this medication with food**. This helps increase absorption and significantly reduces the chance of stomach upset or vomiting. * **Treatment Duration:** Fungal infections (like ringworm) take time to heal. You may need to give this medication for several weeks or months. **Do not stop early**, even if your pet looks better, unless instructed by your veterinarian. * **What to Watch For:** Terbinafine is generally very safe. However, contact your veterinarian if your pet experiences persistent vomiting, loss of appetite, severe diarrhea, or extreme tiredness. * **Rare but Serious Signs:** In very rare cases, this drug can affect the liver. Call your vet immediately if you notice a yellowing of the eyes, gums, or skin (jaundice). * **Cost:** Be aware that a full course of treatment can be relatively expensive, though generic options have made it more affordable.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Dermatophytic infections (Pulse therapy)
- Dermatophytic infections
- Dermatophytic infections (when other drugs are not tolerated)
- Dermatophyte (M. canis) mycetomas
- Cryptococcal infections (azole-resistant)
- Antifungal (Systemic/Dermatophytosis)
- Localized Malassezia infections
- Avian mycotic infections (Aspergillus)
- Avian mycotic infections (Aspergillus)
- Avian mycotic infections
- Avian mycotic infections
- Aspergillosis (suspected via leukocytosis and pulmonary nodules)
- Dermatophytic infections
給藥方式
可能的副作用
- Vomiting
- Inappetence
- Diarrhea
- Lethargy (reported in cats)
- Hepatotoxicity / Liver failure (very rare, reported in humans)
- Neutropenia (very rare, reported in humans)
- Serious skin reactions like Toxic Epidermal Necrolysis or Stevens-Johnson syndrome (very rare, reported in humans)
- Diarrhoea
- Increased liver enzymes
- Pruritus (cats)
- Topical irritation (due to alcohol content in topical solutions)
- Transient deafness or impaired hearing (in elderly dogs after administration of ear gel)
注意事項與禁忌
- Known hypersensitivity to terbinafine
- Active or chronic liver disease
- Significantly impaired renal function
- Perforated eardrum (for ear gel administration)
- Generalized demodicosis (topical or systemic use)
- Pregnant animals
- Breeding animals
- > **Hepatic and Renal Warning:** Use with extreme caution, if at all, in patients with markedly impaired liver or renal function. Dosage adjustments should be considered if use is unavoidable. * **Pregnancy/Nursing:** Definitive safety in pregnancy has not been established (FDA Category B in humans). The manufacturer recommends against use in pregnant or nursing individuals, as the drug concentrates in maternal milk at levels 7 times higher than plasma. Use with caution in nursing veterinary patients.
藥物相互作用
- Cyclosporine: Terbinafine may increase the elimination and decrease the efficacy of cyclosporine.
- Rifampin: May increase terbinafine clearance, potentially requiring higher terbinafine doses.
- Beta-blockers: Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of beta-blockers.
- MAO Inhibitors (e.g., amitraz, selegiline): Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of MAOIs.
- SSRIs (e.g., fluoxetine): Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of SSRIs.
- Tricyclic Antidepressants: Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of TCAs.
- Cimetidine: May decrease the clearance of terbinafine, potentially increasing plasma concentrations (Clinical Pearl)
常見問題
Terbinafine用於寵物有甚麼用途？
### Important Information for Pet Owners * **Administration:** It is highly recommended to **give this medication with food**. This helps increase absorption and significantly reduces the chance of stomach upset or vomiting. * **Treatment Duration:** Fungal infections (like ringworm) take time to heal. You may need to give this medication for several weeks or months. **Do not stop early**, even if your pet looks better, unless instructed by your veterinarian. * **What to Watch For:** Terbinafine is generally very safe. However, contact your veterinarian if your pet experiences persistent vomiting, loss of appetite, severe diarrhea, or extreme tiredness. * **Rare but Serious Signs:** In very rare cases, this drug can affect the liver. Call your vet immediately if you notice a yellowing of the eyes, gums, or skin (jaundice). * **Cost:** Be aware that a full course of treatment can be relatively expensive, though generic options have made it more affordable.
Terbinafine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。