Piroxicam
別名: Feldene, Brexidol
Piroxicam is a strong anti-inflammatory medication often used to help treat certain types of cancer in pets. * **Give with food:** This can help reduce the chance of stomach upset. * **Watch for stomach ulcers:** Stop the medication and contact your veterinarian immediately if your pet stops eating, vomits (especially if it looks like coffee grounds or has blood), or has dark, tarry stools. * **Do not mix medications:** Never give your pet aspirin, other NSAIDs (like Rimadyl, Metacam), or steroids (like prednisone) while they are taking piroxicam unless explicitly directed by your veterinarian. * **Strict dosing:** Do not exceed the prescribed dose, as the safety margin for this drug is very narrow in pets.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy of transitional cell carcinomas
- Adjunctive therapy of transitional cell carcinomas/neoplastic diseases
- Cancer pain
- Antiinflammatory/analgesic
- Idiopathic chronic rhinosinusitis
- All uses (e.g., various neoplasms)
- Mucocutaneous squamous cell carcinoma
- Squamous cell carcinoma of the third eyelid after surgical excision
- Fracture associated limb swelling (Rabbits)
- Adjunctive therapy of transitional cell carcinomas, squamous cell carcinomas, and palliative therapy for other neoplastic diseases
- Adjunctive therapy of neoplastic diseases (for dogs who tolerate NSAIDs poorly)
- Adjuvant therapy for splenic hemangiosarcoma (stage II)
給藥方式
可能的副作用
- Gastrointestinal ulceration and bleeding (melena, hematemesis)
- Vomiting, anorexia, and diarrhea
- Renal papillary necrosis
- Peritonitis (secondary to GI perforation)
- Decreased hematocrit (anecdotal in cats)
- Peripheral edema
- Elevated liver enzymes
- Gastrointestinal toxicity
- Gastric ulceration
- Ulcerative skin lesions (reported in cats)
- Potential precipitation of cardiac failure (known in humans, unknown risk in animals)
注意事項與禁忌
- Hypersensitivity to piroxicam, aspirin, or other NSAIDs
- Active or history of gastrointestinal ulcer disease
- Bleeding disorders
- Gastric ulceration
- Renal disease
- Concurrent use of corticosteroids
- Concurrent use of other NSAIDs
- Dehydration (relative contraindication due to renal risk)
- **Extreme Caution:** Use in cats is controversial and must be done with extreme caution due to lack of safety studies and potential for severe GI/renal toxicity. **Caution:** Use carefully in patients with severely compromised cardiac function due to potential for peripheral edema. The therapeutic window in dogs is very narrow; doses as low as 1 mg/kg daily have caused severe GI ulceration and peritonitis.
藥物相互作用
- Aminoglycosides (gentamicin, amikacin): Increased risk for nephrotoxicity
- Anticoagulants (heparin, LMWH, warfarin): Increased risk for bleeding
- Aspirin: Decreased piroxicam plasma levels and increased likelihood of GI adverse effects (blood loss); do not use concurrently
- Bisphosphonates (alendronate): May increase risk for GI ulceration
- Cisplatin: May potentiate the renal toxicity of cisplatin
- Corticosteroids: Significantly increased risk for GI adverse effects and ulceration
- Furosemide: May reduce the saluretic and diuretic effects of furosemide
- Highly protein-bound drugs (phenytoin, valproic acid, sulfonamides): Piroxicam is 99% protein-bound and may displace other drugs, increasing their serum levels and duration of action
- Methotrexate: Serious toxicity has occurred when used concomitantly; use with extreme caution
- Other NSAIDs: Increased risk of severe gastric ulceration and GI toxicity
- Diuretics: Increased risk of nephrotoxicity and renal papillary necrosis
常見問題
Piroxicam用於寵物有甚麼用途？
Piroxicam is a strong anti-inflammatory medication often used to help treat certain types of cancer in pets. * **Give with food:** This can help reduce the chance of stomach upset. * **Watch for stomach ulcers:** Stop the medication and contact your veterinarian immediately if your pet stops eating, vomits (especially if it looks like coffee grounds or has blood), or has dark, tarry stools. * **Do not mix medications:** Never give your pet aspirin, other NSAIDs (like Rimadyl, Metacam), or steroids (like prednisone) while they are taking piroxicam unless explicitly directed by your veterinarian. * **Strict dosing:** Do not exceed the prescribed dose, as the safety margin for this drug is very narrow in pets.
Piroxicam對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。