Megestrol Acetate
別名: Ovaban, Megace, Ovarid
Megestrol acetate is a powerful hormone medication. While it can be effective, it carries significant risks, especially in cats. * **Understand the Risks**: This drug can cause serious side effects, including diabetes, severe uterine infections (pyometra), and suppression of the adrenal glands. * **Monitor Closely**: Watch your pet's water intake and urination closely. If they start drinking or urinating excessively, contact your veterinarian immediately, as this could be a sign of diabetes. * **Physical Changes**: Check your pet's mammary glands (belly area) regularly for any swelling, lumps, or discharge. Report any changes to your vet. * **Behavior and Energy**: Note any extreme lethargy, weakness, or sudden changes in behavior. * **Do Not Stop Abruptly**: If your pet has been on this medication long-term, do not stop it suddenly without consulting your veterinarian, as their body may need time to adjust. * **Human Safety**: Pregnant women should avoid handling this medication.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Suppression of estrus (in anestrus)
- Suppression of estrus (in proestrus)
- Suppression of estrus (behavioral estrus)
- Postponement of estrus (started during diestrus)
- Postponement of estrus (started during anestrus)
- Prevention of estrus
- Idiopathic feline miliary dermatitis
- Appetite stimulant
- Alternative treatment for immune-mediated skin diseases
- Adjunctive therapy of eosinophilic granulomas
- Eosinophilic ulcers
- Feline atopy ('last ditch' alternative)
- Feline plasma cell gingivitis
給藥方式
可能的副作用
- Profound adrenocortical suppression (especially in cats)
- Transient or permanent diabetes mellitus
- Cystic endometrial hyperplasia (CEH) and pyometra
- Mammary hypertrophy and neoplasia
- Increased appetite and weight gain
- Polydipsia and polyuria (PU/PD)
- Lethargy and personality changes
- Hepatotoxicity (rare)
- Acromegaly (dogs)
- Lactation (rare)
注意事項與禁忌
- Pregnancy
- Uterine disease (e.g., pyometra, endometritis)
- Diabetes mellitus
- Mammary neoplasias
- Prior to the first estrous cycle in dogs
- Anestrus therapy in dogs with abnormal cycles
- During diestrus or in the presence of uterine hemorrhage
- Treatment of pseudopregnancy in bitches (per manufacturer, though off-label protocols exist)
- > **Black Box Warning Equivalent**: Megestrol acetate can induce profound, life-threatening adrenocortical suppression and iatrogenic Addisonian crisis, particularly in cats. * **Adrenal Suppression**: Because of its glucocorticoid activity, patients may require exogenous stress-dose steroids during periods of trauma, surgery, or severe illness. * **Reproductive Risks**: High risk of inducing cystic endometrial hyperplasia (CEH) and pyometra. A thorough reproductive history, physical exam, mammary palpation, and vaginal cytology are strongly recommended before initiating therapy for reproductive control. * **Infection Risk**: May exacerbate latent viral infections (e.g., Feline Herpesvirus-1). * **Human Safety**: Pregnant women should handle this medication with extreme caution (FDA Category X in early pregnancy).
藥物相互作用
- Corticosteroids: Concurrent long-term use may exacerbate adrenocortical suppression and increase the risk of diabetes mellitus.
- Rifampin: May decrease progestin activity due to microsomal enzyme induction, resulting in increased progestin metabolism.
常見問題
Megestrol Acetate用於寵物有甚麼用途？
Megestrol acetate is a powerful hormone medication. While it can be effective, it carries significant risks, especially in cats. * **Understand the Risks**: This drug can cause serious side effects, including diabetes, severe uterine infections (pyometra), and suppression of the adrenal glands. * **Monitor Closely**: Watch your pet's water intake and urination closely. If they start drinking or urinating excessively, contact your veterinarian immediately, as this could be a sign of diabetes. * **Physical Changes**: Check your pet's mammary glands (belly area) regularly for any swelling, lumps, or discharge. Report any changes to your vet. * **Behavior and Energy**: Note any extreme lethargy, weakness, or sudden changes in behavior. * **Do Not Stop Abruptly**: If your pet has been on this medication long-term, do not stop it suddenly without consulting your veterinarian, as their body may need time to adjust. * **Human Safety**: Pregnant women should avoid handling this medication.
Megestrol Acetate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。