醋酸甲地孕酮
別名: Ovaban, Megace, Ovarid
醋酸甲地孕酮是一種強效的荷爾蒙藥物。雖然它可能有效，但伴隨著顯著的風險，特別是在貓身上。 * **了解風險**：此藥物可能引起嚴重的副作用，包括糖尿病、嚴重的子宮感染（子宮蓄膿）以及腎上腺抑制。 * **密切監測**：密切觀察寵物的飲水量和排尿量。如果牠們開始過度飲水或排尿，請立即聯繫獸醫，因為這可能是糖尿病的徵兆。 * **身體變化**：定期檢查寵物的乳腺（腹部區域）是否有腫脹、腫塊或分泌物。如有任何變化請向獸醫報告。 * **行為與活力**：注意是否有極度嗜睡、虛弱或行為上的突然改變。 * **請勿突然停藥**：如果您的寵物長期服用此藥，請勿在未諮詢獸醫的情況下突然停藥，因為牠們的身體需要時間適應。 * **人類安全**：孕婦應避免接觸此藥物。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Suppression of estrus (in anestrus)
- Suppression of estrus (in proestrus)
- Suppression of estrus (behavioral estrus)
- Postponement of estrus (started during diestrus)
- Postponement of estrus (started during anestrus)
- Prevention of estrus
- Idiopathic feline miliary dermatitis
- Appetite stimulant
- Alternative treatment for immune-mediated skin diseases
- Adjunctive therapy of eosinophilic granulomas
- Eosinophilic ulcers
- Feline atopy ('last ditch' alternative)
- Feline plasma cell gingivitis
- Feline endocrine alopecia (FEA)
- Feline psychogenic alopecia and dermatitis
- Persistent hematuria and urethritis in a non-obstructed cat
- Urine marking, intraspecies aggression, anxiety
- To reduce marking in neutered male cats
- Urine marking, intraspecies aggression, anxiety
- To halt cycle in proestrus
- To postpone an anticipated cycle
- To delay an anticipated heat during anestrus
- Estrus suppression (general)
- Temporary estrus postponement (general)
- Benign prostatic hypertrophy
- Benign prostatic hypertrophy
- Benign prostatic hypertrophy
- Pseudocyesis (false pregnancy)
- To prevent vaginal hyperplasia development
- Treatment of severe galactorrhea
- Adjunctive treatment of aggressive or unacceptable masculine behavior
給藥方式
可能的副作用
- Profound adrenocortical suppression (especially in cats)
- Transient or permanent diabetes mellitus
- Cystic endometrial hyperplasia (CEH) and pyometra
- Mammary hypertrophy and neoplasia
- Increased appetite and weight gain
- Polydipsia and polyuria (PU/PD)
- Lethargy and personality changes
- Hepatotoxicity (rare)
- Acromegaly (dogs)
- Lactation (rare)
注意事項與禁忌
- Pregnancy
- Uterine disease (e.g., pyometra, endometritis)
- Diabetes mellitus
- Mammary neoplasias
- Prior to the first estrous cycle in dogs
- Anestrus therapy in dogs with abnormal cycles
- During diestrus or in the presence of uterine hemorrhage
- Treatment of pseudopregnancy in bitches (per manufacturer, though off-label protocols exist)
- > **Black Box Warning Equivalent**: Megestrol acetate can induce profound, life-threatening adrenocortical suppression and iatrogenic Addisonian crisis, particularly in cats. * **Adrenal Suppression**: Because of its glucocorticoid activity, patients may require exogenous stress-dose steroids during periods of trauma, surgery, or severe illness. * **Reproductive Risks**: High risk of inducing cystic endometrial hyperplasia (CEH) and pyometra. A thorough reproductive history, physical exam, mammary palpation, and vaginal cytology are strongly recommended before initiating therapy for reproductive control. * **Infection Risk**: May exacerbate latent viral infections (e.g., Feline Herpesvirus-1). * **Human Safety**: Pregnant women should handle this medication with extreme caution (FDA Category X in early pregnancy).
藥物相互作用
- Corticosteroids: Concurrent long-term use may exacerbate adrenocortical suppression and increase the risk of diabetes mellitus.
- Rifampin: May decrease progestin activity due to microsomal enzyme induction, resulting in increased progestin metabolism.
常見問題
醋酸甲地孕酮用於寵物有什麼用途？
醋酸甲地孕酮是一種強效的荷爾蒙藥物。雖然它可能有效，但伴隨著顯著的風險，特別是在貓身上。 • 了解風險：此藥物可能引起嚴重的副作用，包括糖尿病、嚴重的子宮感染（子宮蓄膿）以及腎上腺抑制。 • 密切監測：密切觀察寵物的飲水量和排尿量。如果牠們開始過度飲水或排尿，請立即聯繫獸醫，因為這可能是糖尿病的徵兆。 • 身體變化：定期檢查寵物的乳腺（腹部區域）是否有腫脹、腫塊或分泌物。如有任何變化請向獸醫報告。 • 行為與活力：注意是否有極度嗜睡、虛弱或行為上的突然改變。 • 請勿突然停藥：如果您的寵物長期服用此藥，請勿在未諮詢獸醫的情況下突然停藥，因為牠們的身體需要時間適應。 • 人類安全：孕婦應避免接觸此藥物。
醋酸甲地孕酮對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。