Epoetin Alfa
別名: Epogen, Procrit, Eprex, NeoRecormon, Neorecormon
- **Administration:** If giving injections at home, ensure you have been properly trained by your veterinary team on subcutaneous injection techniques. - **Storage:** Keep the medication in the refrigerator (2-8°C). **Do not freeze** and **do not shake** the vial, as shaking can destroy the active protein. - **Monitoring:** Keep all scheduled appointments for blood tests. Frequent monitoring of red blood cell counts (PCV) and blood pressure is critical. - **Warning Signs:** Contact your veterinarian immediately if your pet becomes increasingly lethargic, weak, or loses their appetite, as this could indicate a dangerous immune reaction (autoantibody formation) causing the anemia to worsen.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy for anemia associated with endstage renal disease
- Anemia associated with endstage renal disease (PCV <20%)
- Problematic clinical signs and PCV <20%
- Anemia
- Anemia (Rabbits)
- Adjunctive therapy for anemia associated with endstage renal disease
- Adjunctive therapy for anemia associated with endstage renal disease
給藥方式
可能的副作用
- Autoantibody formation (leading to refractory anemia)
- Systemic hypertension
- Vomiting
- Seizures
- Uveitis
- Iron depletion
- Local reactions at injection sites
- Fever
- Arthralgia
- Mucocutaneous ulcers
- Polycythemia (with chronic overdosage)
注意事項與禁忌
- Uncontrolled hypertension
- Hypersensitivity to epoetin alfa
- Formation of significant autoantibodies with prior treatment
- Equines (not recommended for use)
- Therapy should be started with caution or withheld until corrected in animals with **moderate to severe hypertension** or **iron deficiency**. **Autoantibody Risk:** Up to 30% of patients may develop antibodies significant enough to cause profound anemia and arrestment of erythropoiesis. A bone marrow aspirate showing a myeloid:erythroid ratio >6 predicts significant autoantibody formation and contraindicates further therapy. Discontinue therapy if polycythemia, fever, anorexia, joint pain, cellulitis, or cutaneous/mucosal ulceration occurs.
藥物相互作用
- Androgens: May increase the sensitivity of erythroid progenitors; safety of this combination is not fully determined.
- Desmopressin: Concurrent use with EPO can decrease bleeding times.
- Probenecid: Has been demonstrated to reduce the renal tubular excretion of EPO; clinical significance remains unclear.
- Iron supplements: Synergistic/Required; EPO increases demand for iron to synthesize hemoglobin for new RBCs
常見問題
Epoetin Alfa用於寵物有甚麼用途？
- **Administration:** If giving injections at home, ensure you have been properly trained by your veterinary team on subcutaneous injection techniques. - **Storage:** Keep the medication in the refrigerator (2-8°C). **Do not freeze** and **do not shake** the vial, as shaking can destroy the active protein. - **Monitoring:** Keep all scheduled appointments for blood tests. Frequent monitoring of red blood cell counts (PCV) and blood pressure is critical. - **Warning Signs:** Contact your veterinarian immediately if your pet becomes increasingly lethargic, weak, or loses their appetite, as this could indicate a dangerous immune reaction (autoantibody formation) causing the anemia to worsen.
Epoetin Alfa對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。