阿法依泊汀 (紅血球生成素)
別名: Epogen, Procrit, Eprex, NeoRecormon, Neorecormon
藥物類別: Erythropoietic Agent
若在家中自行施打，需接受獸醫團隊正確的皮下注射訓練。**請冷藏保存（2-8°C），切勿冷凍或搖晃藥瓶**（搖晃會破壞蛋白質活性）。治療期間需定期回診抽血，監測紅血球容積比 (PCV)、血壓及鐵質狀態。若寵物出現異常疲倦、虛弱或食慾不振，這可能是自體抗體產生的警訊，請立即聯繫獸醫師。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Adjunctive therapy for anemia associated with endstage renal disease
- Anemia associated with endstage renal disease (PCV <20%)
- Problematic clinical signs and PCV <20%
- Anemia
- Anemia (Rabbits)
- Adjunctive therapy for anemia associated with endstage renal disease
- Adjunctive therapy for anemia associated with endstage renal disease
給藥方式
SCIM
可能的副作用
- Autoantibody formation (leading to refractory anemia)
- Systemic hypertension
- Vomiting
- Seizures
- Uveitis
- Iron depletion
- Local reactions at injection sites
- Fever
- Arthralgia
- Mucocutaneous ulcers
- Polycythemia (with chronic overdosage)
注意事項與禁忌
- Uncontrolled hypertension
- Hypersensitivity to epoetin alfa
- Formation of significant autoantibodies with prior treatment
- Equines (not recommended for use)
- Therapy should be started with caution or withheld until corrected in animals with **moderate to severe hypertension** or **iron deficiency**. **Autoantibody Risk:** Up to 30% of patients may develop antibodies significant enough to cause profound anemia and arrestment of erythropoiesis. A bone marrow aspirate showing a myeloid:erythroid ratio >6 predicts significant autoantibody formation and contraindicates further therapy. Discontinue therapy if polycythemia, fever, anorexia, joint pain, cellulitis, or cutaneous/mucosal ulceration occurs.
藥物相互作用
- Androgens: May increase the sensitivity of erythroid progenitors; safety of this combination is not fully determined.
- Desmopressin: Concurrent use with EPO can decrease bleeding times.
- Probenecid: Has been demonstrated to reduce the renal tubular excretion of EPO; clinical significance remains unclear.
- Iron supplements: Synergistic/Required; EPO increases demand for iron to synthesize hemoglobin for new RBCs
常見問題
阿法依泊汀 (紅血球生成素)用於寵物有甚麼用途？
若在家中自行施打，需接受獸醫團隊正確的皮下注射訓練。請冷藏保存（2-8°C），切勿冷凍或搖晃藥瓶（搖晃會破壞蛋白質活性）。治療期間需定期回診抽血，監測紅血球容積比 (PCV)、血壓及鐵質狀態。若寵物出現異常疲倦、虛弱或食慾不振，這可能是自體抗體產生的警訊，請立即聯繫獸醫師。
阿法依泊汀 (紅血球生成素)對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。