Dobutamine
別名: Dobutrex, Posiject
> **Note:** Dobutamine is strictly an intensive care medication and is not prescribed for home use. - **Purpose:** This medication is given as a continuous intravenous (IV) drip to help your pet's heart pump more effectively during a critical illness, shock, or severe heart failure crisis. - **Monitoring:** Your pet will be kept in the ICU where veterinary professionals can continuously monitor their heart rate, ECG, and blood pressure. - **Safety:** Because the drug works very quickly and leaves the body rapidly, the veterinary team can easily adjust the dose minute-by-minute to ensure your pet's safety and comfort.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Short-term treatment of acute heart failure
- Unspecified cardiac support
- Unspecified cardiac support
- Short-term inotropic support (heart failure, shock, anesthesia hypotension)
- Unspecified cardiac support
- Hemodynamic support in foals (after volume repletion)
- Short-term treatment of acute heart failure
- Shock where fluid therapy alone not adequate
- Severe, decompensated, congestive heart failure
- Short-term treatment of low cardiac output and acute heart failure
- Hemodynamic support
- Unspecified cardiac support
- Vasodilatory shock if fluid resuscitation is not successful
給藥方式
可能的副作用
- Tachycardia
- Facial twitching (especially in dogs)
- Seizures
- Tachyphylaxis (increasing dosages required over time)
- CNS effects such as tremors or seizures (especially in cats at >5 mcg/kg/min)
- Ectopic beats
- Increased blood pressure
- Chest pain and palpitations (reported in humans)
- Proarrhythmia (ventricular arrhythmias)
- Hypertension
- Hypokalaemia (with prolonged use)
- Nausea
- Vomiting
- Seizures (particularly in cats at higher doses)
注意事項與禁忌
- Known hypersensitivity to dobutamine or the preservative sodium bisulfite
- Idiopathic hypertrophic subaortic stenosis (IHSS)
- Uncorrected hypovolemic states
- Cardiac outflow obstruction (e.g., aortic stenosis)
- > **Warning:** Hypovolemic states must be corrected before administering dobutamine. - **Cardiac Arrhythmias:** Use with extreme caution in patients with ventricular tachyarrhythmias or atrial fibrillation. Dobutamine can enhance atrioventricular conduction; animals with atrial fibrillation should be digitalized prior to receiving dobutamine. - **Myocardial Infarction:** Use very cautiously post-MI as it may increase myocardial oxygen demand and infarct size. - **Equine Electrocardioversion:** In horses receiving electrocardioversion for atrial fibrillation, stop dobutamine for at least 5 minutes before shock delivery.
藥物相互作用
- Halogenated hydrocarbon anesthetics (e.g., halothane, cyclopropane): May result in increased incidences of ventricular arrhythmias
- Beta-blockers (e.g., metoprolol, propranolol): May antagonize the cardiac effects of dobutamine, resulting in a preponderance of alpha-adrenergic effects and increased total peripheral resistance
- Nitroprusside: Synergistic effects (increased cardiac output and reduced wedge pressure) can result
- Oxytocic drugs: May induce severe hypertension when used with dobutamine in obstetric patients
- Insulin: Increased insulin requirements in diabetic patients
- Propranolol: Increased systemic vascular resistance
- Doxapram: Increased systemic vascular resistance
- Selegiline: Increased systemic vascular resistance (MAOI interaction)
- Halothane: Increased incidence of arrhythmias
- Digoxin: Recommended prior/concurrently in cases of atrial fibrillation to prevent increased ventricular rate
常見問題
Dobutamine用於寵物有甚麼用途？
> **Note:** Dobutamine is strictly an intensive care medication and is not prescribed for home use. - **Purpose:** This medication is given as a continuous intravenous (IV) drip to help your pet's heart pump more effectively during a critical illness, shock, or severe heart failure crisis. - **Monitoring:** Your pet will be kept in the ICU where veterinary professionals can continuously monitor their heart rate, ECG, and blood pressure. - **Safety:** Because the drug works very quickly and leaves the body rapidly, the veterinary team can easily adjust the dose minute-by-minute to ensure your pet's safety and comfort.
Dobutamine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。