Colchicine
別名: Colcrys, Artrex, Colchily, Colchicquim, Colchis, Colcine, Colgout, Goutichine, Goutnil, Reugot, Ticolcin, Tolchicine, Colchicine
### Important Information for Pet Owners Colchicine is a specialized medication used to treat specific liver conditions or genetic fever syndromes (such as in Shar-Peis). Because it is a potent drug, careful monitoring is essential. - **Watch for Stomach Upset:** The most common and earliest signs of a problem are **nausea, vomiting, diarrhea, or loss of appetite**. If you notice *any* of these, **stop the medication and contact your veterinarian immediately**. - **Investigational Use:** This drug is often used 'off-label' in veterinary medicine, meaning it is prescribed based on clinical experience rather than formal veterinary approval. - **Safety Precautions:** - Keep this medication strictly out of reach of children and other pets. Even a small accidental dose can be highly dangerous. - **Pregnant women** should avoid handling the medication or coming into contact with the treated pet's urine. If you must handle it, wear gloves.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Fibrosis
- As an antifibrotic for the adjunctive treatment of hepatic fibrosis (Psittacines)
- Adjunctive treatment of hepatic cirrhosis/fibrosis
- Adjunctive treatment of hepatic cirrhosis/fibrosis
- Periodic fever syndrome in Shar Pei dogs
- To reduce the frequency and severity of fever and prevent the development of amyloidosis in dogs with Shar Pei Fever
- Fibrosis / Renal amyloidosis
給藥方式
可能的副作用
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Anorexia
- Bone marrow suppression (with prolonged use)
- Neutropenia (rare)
- Severe local irritation/thrombophlebitis (if extravasated IV)
- Diarrhoea
- Renal damage (rare)
- Bone marrow suppression (rare)
- Myopathy (rare)
- Peripheral neuropathy (rare)
- Increased serum ALP
注意事項與禁忌
- Serious renal dysfunction
- Serious gastrointestinal dysfunction
- Serious cardiac dysfunction
- Pregnancy (unless benefits strictly outweigh risks)
- Pregnancy
- Severe renal impairment
- ### Contraindications & Warnings - **Absolute Contraindications:** Patients with serious renal, gastrointestinal, or cardiac dysfunction. - **Caution:** Use with extreme care in geriatric or debilitated patients, and those in the early stages of organ dysfunction. - **Reproductive Safety:** Colchicine is **teratogenic** (FDA Category C for oral, Category D for parenteral) and reduces spermatogenesis. Use during pregnancy only if the potential benefits strictly outweigh the risks. Use cautiously in nursing mothers. - **Veterinary Status:** Use is considered somewhat controversial and experimental, as safety and efficacy are not definitively documented in all target species.
藥物相互作用
- Bone Marrow Depressants (e.g., antineoplastics, immunosuppressants, chloramphenicol, amphotericin B): May cause additive myelosuppression when used concurrently with colchicine.
- Ciclosporin: Possible increased risk of nephrotoxicity and myotoxicity
- NSAIDs (e.g., Phenylbutazone): May increase the risks of thrombocytopenia, leucopenia, or bone marrow depression
- Anticancer chemotherapeutics: May cause additive myelosuppressive effects
常見問題
Colchicine用於寵物有甚麼用途？
### Important Information for Pet Owners Colchicine is a specialized medication used to treat specific liver conditions or genetic fever syndromes (such as in Shar-Peis). Because it is a potent drug, careful monitoring is essential. - **Watch for Stomach Upset:** The most common and earliest signs of a problem are **nausea, vomiting, diarrhea, or loss of appetite**. If you notice *any* of these, **stop the medication and contact your veterinarian immediately**. - **Investigational Use:** This drug is often used 'off-label' in veterinary medicine, meaning it is prescribed based on clinical experience rather than formal veterinary approval. - **Safety Precautions:** - Keep this medication strictly out of reach of children and other pets. Even a small accidental dose can be highly dangerous. - **Pregnant women** should avoid handling the medication or coming into contact with the treated pet's urine. If you must handle it, wear gloves.
Colchicine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。