Cisapride
別名: Propulsid
- **Administration:** Give exactly as prescribed, ideally **15 to 30 minutes before a meal** for maximum effectiveness. - **Sourcing:** This medication is no longer commercially manufactured and must be specially made by a veterinary compounding pharmacy. - **Side Effects:** Generally very safe for pets. Watch for mild stomach upset, vomiting, or diarrhea. Report any unusual lethargy or abnormal behavior to your veterinarian. - **Interactions:** Inform your vet about *all* medications and supplements your pet is taking, as cisapride has many significant drug interactions that can be dangerous.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For chronic constipation (e.g., megacolon)
- For chronic constipation (e.g., megacolon)
- For chronic constipation (e.g., megacolon)
- For chronic constipation (e.g., megacolon)
- For gastric stasis
- To reduce the risk for esophageal stricture formation in cases of esophagitis
- As a promotility agent (Foals with periparturient asphyxia)
- Promotility (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas)
- For ileus if GI tract not obstructed in Guinea pigs, chinchillas
- GI stasis (Rabbits)
- For gastric stasis in rabbits
- As a promotility agent
- To reduce regurgitation associated with megaesophagus
給藥方式
可能的副作用
- Vomiting
- Diarrhea
- Abdominal discomfort
- Prolonged QT intervals or cardiac arrhythmias (very rare in veterinary patients)
注意事項與禁忌
- Gastrointestinal perforation
- Gastrointestinal obstruction
- Gastrointestinal hemorrhage
- Hypersensitivity to cisapride
- Use with caution in pregnant or nursing animals; high doses caused embryotoxicity and fetotoxicity in lab animals. Dosage may need to be decreased in patients with severe hepatic impairment. Avoid concurrent use with CYP3A4 inhibitors or QT-prolonging drugs due to the risk of severe cardiac arrhythmias.
藥物相互作用
- Anticholinergic agents: May diminish the prokinetic effects of cisapride.
- Benzodiazepines: Cisapride may enhance the sedative effects of benzodiazepines.
- Warfarin: Cisapride may enhance anticoagulant effects; additional monitoring and dosage adjustments may be required.
- Oral drugs with a narrow therapeutic index: Cisapride decreases GI transit times, potentially altering the absorption of other oral drugs. Serum levels may need closer monitoring.
- CYP3A4 Inhibitors (Amiodarone, Ketoconazole, Itraconazole, Fluconazole, Chloramphenicol, Cimetidine, Fluvoxamine, Grapefruit juice, Macrolides except azithromycin): Inhibit cisapride metabolism, leading to increased cisapride levels and an increased risk for cisapride cardiotoxicity.
- QT-prolonging drugs (Amiodarone, Clarithromycin, Moxifloxacin, Procainamide, Quinidine, Sotalol, Tricyclic Antidepressants): May increase the risk of QT interval prolongation and fatal arrhythmias when used concurrently with cisapride.
常見問題
Cisapride用於寵物有甚麼用途？
- **Administration:** Give exactly as prescribed, ideally **15 to 30 minutes before a meal** for maximum effectiveness. - **Sourcing:** This medication is no longer commercially manufactured and must be specially made by a veterinary compounding pharmacy. - **Side Effects:** Generally very safe for pets. Watch for mild stomach upset, vomiting, or diarrhea. Report any unusual lethargy or abnormal behavior to your veterinarian. - **Interactions:** Inform your vet about *all* medications and supplements your pet is taking, as cisapride has many significant drug interactions that can be dangerous.
Cisapride對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。