Chlorpromazine
別名: Thorazine, aminazine
* **Handling:** Avoid getting the liquid solution on your hands or clothing, as it can cause contact dermatitis (skin irritation). Wash hands after administration. * **Urine Color:** This medication may discolor your pet's urine to a pink or red-brown color. This is a normal side effect and is not a cause for concern. * **Observation:** Keep your pet in a safe, quiet environment while sedated. Watch for excessive lethargy, unusual muscle tremors, or stiffness, and contact your veterinarian if these occur.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- General use
- General use
- General use
- As an antiemetic
- As an antiemetic
- As a preanesthetic
- Premedication for cattle undergoing standing procedures
- Premedication
- Premedication
- Restraint
- Prior to barbiturate anesthesia
- As an antiemetic
- As an antiemetic
- As an antiemetic
給藥方式
可能的副作用
- Hypotension
- CNS stimulation (paradoxical)
- Bradycardia or tachycardia
- Extrapyramidal signs in cats (tremors, shivering, rigidity, loss of righting reflexes)
- Lethargy
- Diarrhea
- Loss of anal sphincter tone
- Ataxia, excitation, and panic reactions in horses
- Hypothermia or hyperthermia
注意事項與禁忌
- Horses (generally not recommended due to severe ataxia and panic reactions)
- Rabbits (IM injection causes severe muscle discomfort and swelling)
- Hypovolemia or shock
- Tetanus or strychnine intoxication (due to extrapyramidal effects)
- > **Important:** Intravenous injections must be diluted with saline to concentrations of no more than 1 mg/mL and administered slowly. Do not inject into arteries. * **MDR1 Mutation:** Dogs with MDR1 mutations (Collies, Australian Shepherds, etc.) may develop pronounced and prolonged sedation. Reduce initial doses by 25% in suspect patients. * **Aggressive Dogs:** Use cautiously as a restraining agent; it may make the animal more prone to startle and react to noises or sensory inputs. * **Debilitated Patients:** Use cautiously and in smaller doses in animals with hepatic dysfunction, cardiac disease, or general debilitation. * **Anesthesia:** Animals may require lower dosages of general anesthetics following phenothiazines.
藥物相互作用
- Acetaminophen: Possible increased risk for hypothermia
- Antacids: May cause reduced GI absorption of oral phenothiazines
- Antidiarrheal mixtures (e.g., kaolin/pectin, bismuth subsalicylate): May cause reduced GI absorption of oral phenothiazines
- CNS Depressant Agents (barbiturates, narcotics, anesthetics): May cause additive CNS depression
- Dipyrone: May cause serious hypothermia
- Epinephrine: Phenothiazines block alpha-adrenergic receptors; concomitant epinephrine can lead to unopposed beta-activity causing vasodilation and increased cardiac rate (epinephrine reversal)
- Opiates: May enhance hypotensive effects; chlorpromazine dosages may need reduction
- Organophosphate Agents: Effects may be potentiated; do not give phenothiazines within one month of worming with these agents
- Paraquat: Toxicity may be increased by chlorpromazine
- Phenytoin: Metabolism may be decreased if given concurrently
- Physostigmine: Toxicity may be enhanced by chlorpromazine
常見問題
Chlorpromazine用於寵物有甚麼用途？
* **Handling:** Avoid getting the liquid solution on your hands or clothing, as it can cause contact dermatitis (skin irritation). Wash hands after administration. * **Urine Color:** This medication may discolor your pet's urine to a pink or red-brown color. This is a normal side effect and is not a cause for concern. * **Observation:** Keep your pet in a safe, quiet environment while sedated. Watch for excessive lethargy, unusual muscle tremors, or stiffness, and contact your veterinarian if these occur.
Chlorpromazine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。