Ceftazidime
別名: Fortaz, Ceptaz, Tazicef, Tazidime, Fortum
- **Administration:** Your veterinarian may instruct you to administer this drug via subcutaneous (SC) injection at home. Ensure you are comfortable with the injection technique. - **Storage is Critical:** Reconstituted ceftazidime often requires refrigeration or freezing. If dispensed in frozen syringes, keep them in the freezer until needed. Thaw only the dose you need at room temperature. **Do not refreeze thawed solutions.** - **Side Effects:** Watch for signs of gastrointestinal upset (diarrhea, vomiting) or allergic reactions (facial swelling, hives, difficulty breathing). Contact your veterinarian if these occur. - **Injection Site:** Monitor the injection site for redness, swelling, or pain.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Initial antibiotic therapy of gram-negative infections
- Initial treatment of orthopedic infections
- Initial treatment of soft tissue infections
- Initial treatment of sepsis, bacteremia
- Susceptible infections
- Pseudomonas aeruginosa infections
- Pseudomonas aeruginosa infections (CRI)
- Initial treatment of systemic infections
- Susceptible infections
- Pseudomonas infections
- Susceptible infections
- Bacterial infections in snakes (particularly Enterobacteriaceae or Pseudomonas aeruginosa)
- Chelonians
給藥方式
可能的副作用
- Pain at IM injection site (SC may be less painful)
- Gastrointestinal effects (diarrhea, vomiting)
- Hypersensitivity reactions (allergic reactions)
- Granulocytopenia
- Thrombocytopenia
- Mild azotemia
- Pseudomembranous colitis (C. difficile)
- Increased serum liver enzymes (reported in humans)
注意事項與禁忌
- Known hypersensitivity or prior allergic reaction to cephalosporins
- > **Renal Impairment:** Because the drug is primarily excreted via the kidneys, accumulation may result in patients with significantly impaired renal function. Use with caution and adjust the dose as required. - **Cross-Reactivity:** Up to 16% of humans allergic to penicillins may also be allergic to cephalosporins; the veterinary significance is unclear but warrants caution. - **Laboratory Interference:** May cause a false-positive urine glucose determination when using cupric sulfate solution tests (e.g., Clinitest). May rarely cause positive direct Coombs' tests.
藥物相互作用
- Aminoglycosides / Nephrotoxic drugs (e.g., amphotericin B): Potential additive nephrotoxicity. In vitro synergy exists against certain bacteria, but they must NOT be mixed in the same syringe or fluid bag (administer separately).
- Chloramphenicol: May be antagonistic to ceftazidime's bactericidal effects on gram-negative bacilli; concurrent use is not recommended.
- Oxytetracycline: Bacteriostatic agents may antagonize the bactericidal activity of ceftazidime.
- Erythromycin: Bacteriostatic agents may antagonize the bactericidal activity of ceftazidime.
- Amphotericin B: Increased risk of nephrotoxicity when used concurrently.
- Furosemide: Loop diuretics may increase the risk of nephrotoxicity.
- Aminoglycosides: Synergistic in vivo against Pseudomonas; however, chemically incompatible in vitro (do not mix in the same syringe).
常見問題
Ceftazidime用於寵物有甚麼用途？
- **Administration:** Your veterinarian may instruct you to administer this drug via subcutaneous (SC) injection at home. Ensure you are comfortable with the injection technique. - **Storage is Critical:** Reconstituted ceftazidime often requires refrigeration or freezing. If dispensed in frozen syringes, keep them in the freezer until needed. Thaw only the dose you need at room temperature. **Do not refreeze thawed solutions.** - **Side Effects:** Watch for signs of gastrointestinal upset (diarrhea, vomiting) or allergic reactions (facial swelling, hives, difficulty breathing). Contact your veterinarian if these occur. - **Injection Site:** Monitor the injection site for redness, swelling, or pain.
Ceftazidime對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。