Atovaquone
別名: Mepron, Malanil, Wellvone
**Important Administration Instructions:** * **Give with a fatty meal:** This medication *must* be given with food high in fat (e.g., a small amount of ice cream, tuna oil, butter, or meat fat) to be properly absorbed into your pet's body. Without fat, the drug will not work effectively. * **Shake well:** Gently shake the bottle before drawing up each dose. * **Storage:** Store the liquid at room temperature, away from bright light. Do not freeze it. **What to Watch For:** * This medication is generally well-tolerated, but because it is a newer therapy in veterinary medicine, we are still learning about all potential side effects. * Contact your veterinarian immediately if your pet develops a skin rash, or experiences severe or persistent vomiting or diarrhea. * **Note:** The liquid is bright yellow and can stain fabrics or surfaces, so handle it carefully.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Cytauxzoonosis (Cytauxzoon felis)
- Babesia gibsoni (Asian genotype) infections
- Pneumocystosis
給藥方式
可能的副作用
- Gastrointestinal upset (nausea, vomiting, diarrhea)
- Rashes or hypersensitivity reactions
- Elevated liver enzymes
- CNS effects (headache, dizziness in humans)
- Fever
- Neutropenia and anemia (rare)
注意事項與禁忌
- Patients with a known hypersensitivity to atovaquone
- Patients with severe malabsorption syndromes
- Patients who cannot tolerate oral intake or cannot take the drug with a high-fat meal
- **Administration Warning:** The drug is highly lipophilic and has poor bioavailability on an empty stomach. It **must** be administered with a high-fat meal to ensure adequate systemic absorption. **Toxicity Warning:** Do not use the human combination product Malarone® (atovaquone and proguanil) in dogs due to severe gastrointestinal adverse effects associated with proguanil. **Pregnancy/Nursing:** FDA Category C. Studies in rabbits showed increased maternal and fetal toxicity (decreased fetal growth, early resorption). Use during pregnancy only if the potential benefit justifies the risk. It is excreted in milk in rats, though it is unlikely to pose significant risk to nursing puppies.
藥物相互作用
- Metoclopramide: Can decrease atovaquone plasma concentrations
- Tetracycline: Can decrease atovaquone plasma concentrations
- Rifampin: Can decrease atovaquone plasma concentrations
常見問題
Atovaquone用於寵物有甚麼用途？
**Important Administration Instructions:** * **Give with a fatty meal:** This medication *must* be given with food high in fat (e.g., a small amount of ice cream, tuna oil, butter, or meat fat) to be properly absorbed into your pet's body. Without fat, the drug will not work effectively. * **Shake well:** Gently shake the bottle before drawing up each dose. * **Storage:** Store the liquid at room temperature, away from bright light. Do not freeze it. **What to Watch For:** * This medication is generally well-tolerated, but because it is a newer therapy in veterinary medicine, we are still learning about all potential side effects. * Contact your veterinarian immediately if your pet develops a skin rash, or experiences severe or persistent vomiting or diarrhea. * **Note:** The liquid is bright yellow and can stain fabrics or surfaces, so handle it carefully.
Atovaquone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。