트리메프라진 및 프레드니솔론

용도

• Antipruritic and antitussive therapy
• Treatment of pruritus
• Atopic dermatitis

투여 방법

가능한 부작용

• Sedation
• Depression
• Hypotension
• Extrapyramidal reactions (rigidity, tremors, weakness, restlessness)
• Polyuria (increased urination)
• Polydipsia (increased thirst)
• Polyphagia (increased appetite)
• Elevated liver enzymes
• Weight loss or weight gain
• Vomiting
• Diarrhea
• Iatrogenic hyperadrenocorticism (Cushing's syndrome) with chronic use
• Delayed wound healing
• Osteoporosis

주의사항 및 금기

• Systemic fungal infections
• Hypovolemia or shock
• Tetanus or strychnine intoxication
• Late pregnancy (last trimester) due to risk of inducing parturition
• Use with caution in patients with hepatic dysfunction, cardiac disease, active bacterial or viral infections, peptic ulcers, acute psychoses, corneal ulcers, Cushingoid syndrome, diabetes, osteoporosis, predisposition to thrombophlebitis, hypertension, congestive heart failure (CHF), renal insufficiency, general debilitation, and in very young animals. If used chronically, therapy must be withdrawn gradually to prevent Addisonian crisis. May alter thyroid testing and skin allergy testing.

약물 상호작용

• ACE Inhibitors: Phenothiazines may increase hypotensive effects
• Amphotericin B: Concomitant use with glucocorticoids may cause severe hypokalemia
• Antacids: May cause reduced GI absorption of oral phenothiazines
• Antidiarrheal mixtures (Kaolin/pectin, bismuth): May cause reduced GI absorption of oral phenothiazines
• Anticholinesterase agents (pyridostigmine, neostigmine): In myasthenia gravis patients, concomitant use may lead to profound muscle weakness
• Aspirin (salicylates): Glucocorticoids may reduce salicylate blood levels
• Cisapride: Increased risk for cardiac arrhythmias when used with phenothiazines
• CNS Depressants (barbiturates, narcotics, anesthetics): May cause additive CNS depression
• Cyclophosphamide: Glucocorticoids may inhibit hepatic metabolism of cyclophosphamide
• Cyclosporine: May mutually inhibit hepatic metabolism, increasing blood levels of both drugs
• Digoxin: Increased risk for arrhythmias secondary to glucocorticoid-induced hypokalemia

자주 묻는 질문