테폭살린

용도

• Pain and inflammation associated with osteoarthritis

투여 방법

가능한 부작용

• Diarrhea
• Vomiting
• Anorexia/inappetence
• Enteritis
• Lethargy
• Incoordination (<1%)
• Incontinence (<1%)
• Increased appetite (<1%)
• Eating grass (<1%)
• Flatulence (<1%)
• Hair loss (<1%)
• Trembling (<1%)

주의사항 및 금기

• Prior hypersensitivity reactions to tepoxalin
• Active gastrointestinal ulcers
• Dogs weighing less than 3 kg (cannot be accurately dosed)
• Dogs less than 6 months old (safety not established)
• Use with caution in patients with impaired hepatic, cardiovascular, or renal function, or those at risk for developing nephrotoxic effects associated with NSAIDs (e.g., dehydrated patients or those on concomitant diuretic therapy). Safety has not been determined in pregnant, breeding, or lactating dogs; use with caution and informed consent. Discontinue if signs of inappetence, vomiting, fecal abnormalities, anemia, icterus, or lethargy are observed.

약물 상호작용

• Aspirin: May increase the risk of gastrointestinal toxicity (e.g., ulceration, bleeding, vomiting, diarrhea)
• Corticosteroids: May increase the occurrence of gastric ulceration; avoid concomitant use
• Digoxin: NSAIDs may increase serum levels of digoxin
• Fluconazole: May increase plasma levels of tepoxalin (extrapolated from human celecoxib data)
• Furosemide: NSAIDs may reduce saluretic and diuretic effects
• Methotrexate: Serious toxicity has occurred with concomitant NSAID use; use with extreme caution
• Nephrotoxic Drugs (e.g., aminoglycosides, amphotericin B): May enhance the risk of nephrotoxicity
• Other NSAIDs: May increase the risk of gastrointestinal toxicity (e.g., ulceration, bleeding, vomiting, diarrhea)
• Warfarin: Tepoxalin is highly protein bound (98-99%); may displace warfarin and increase bleeding risk. Monitor closely.

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