세보플루란

용도

• Anesthesia Induction (Mask/Chamber)
• Anesthesia Maintenance (Circle System)
• Induction of anaesthesia (unpremedicated)
• Maintenance of surgical anaesthesia
• Anesthesia Maintenance
• Anesthesia
• Anesthesia Maintenance
• Anesthesia Maintenance
• Anesthesia
• Anesthesia Induction (Mask)
• Anesthesia Maintenance (No Premedication)
• Anesthesia Maintenance (With Premedication)
• Anesthesia Induction (Mask/Chamber)

투여 방법

가능한 부작용

• Dose-dependent hypotension
• Dose-dependent respiratory depression
• Gastrointestinal effects (nausea, vomiting, ileus)
• Myocardial depression and bradycardia (less than halothane)
• Malignant hyperthermia (rare but life-threatening)
• Temporary decreases in erythrocyte, white cell counts, and total protein in ferrets
• Agitation or excitement during rapid recovery
• Neonatal depression (crosses the placental barrier)

주의사항 및 금기

• Patients with a history or predilection towards malignant hyperthermia
• Known hypersensitivity to sevoflurane or other halogenated anaesthetics
• Known or suspected susceptibility to malignant hyperthermia
• > **WARNING: Compound A Formation** > Sevoflurane can react with desiccated (dried out) carbon dioxide absorbents to produce 'Compound A', a known nephrotoxin. Always ensure CO2 absorbents are fresh and avoid using extremely low oxygen flow rates (< 500 mL/min). * **Rapid Action**: Because of its rapid onset, use extreme caution not to overdose during the induction phase. * **Rapid Recovery**: Animals (especially large animals like horses) may wake up abruptly. Appropriate sedation during the recovery phase is critical to prevent injury. * **Neurologic/Renal Disease**: Use with caution in patients with increased CSF pressure, head injury, or renal insufficiency. * **Species Specifics**: * **Rabbits**: Can cause breath holding and struggling; premedication and close observation are required. * **Guinea Pigs**: May have a low margin of safety. * **Geriatric Patients**: May require lower concentrations of inhalation anesthetic.

약물 상호작용

• Aminoglycosides, Lincosamides: May enhance neuromuscular blockade
• Barbiturates (phenobarbital, pentobarbital): May increase concentrations of inorganic fluoride
• Non-depolarizing neuromuscular blocking agents (atracurium, pancuronium, vecuronium): Additive neuromuscular blockade may occur
• Isoniazid: May increase concentrations of inorganic fluoride
• Midazolam: May potentiate sevoflurane effects; decrease MAC
• Opiates: May potentiate sevoflurane effects; decrease MAC
• St. John's Wort: Increased risk for anesthetic complications; recommend discontinuing 5 days in advance of surgery
• Succinylcholine: Sevoflurane may enhance effects
• Sympathomimetics (dopamine, epinephrine, norepinephrine, ephedrine): Sensitizes the myocardium to sympathomimetics (less than halothane); arrhythmias may still result
• Tramadol: May decrease MAC requirements
• Verapamil: May cause cardiodepression

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