프로타민 황산염

용도

• Heparin overdosage
• Heparin overdosage
• Bracken Fern (Pteridium spp.) poisoning
• Heparin overdosage
• Heparin overdosage

투여 방법

가능한 부작용

• Acute hypotension (if given too rapidly)
• Bradycardia
• Pulmonary hypertension
• Dyspnea
• Hypersensitivity/Anaphylaxis
• Heparin 'rebound' effect (bleeding hours after neutralization)
• Hypotension
• Anaphylactoid reactions
• Paradoxical bleeding (at high doses)

주의사항 및 금기

• Known hypersensitivity or intolerance to protamine
• Hypersensitivity to protamine
• Conditions where heparin has not been administered
• ### Administration Warnings * **Rate of Injection:** Must be administered via **slow IV injection** (over 1-3 minutes). Rapid IV injection can cause severe acute hypotension, bradycardia, pulmonary hypertension, and dyspnea. Do not exceed a rate of 50 mg over a 10-minute period. * **Heparin Rebound:** A 'rebound' effect may occur where anticoagulation and bleeding resume several hours after apparent neutralization. This is likely due to the release of heparin from extravascular compartments or degradation of the protamine-heparin complex by fibrinolysin. * **Pregnancy:** FDA Category C. Use only if clearly needed.

약물 상호작용

• Heparin: Forms a stable salt, causing the loss of anticoagulant activity of both compounds (therapeutic intent).

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