포스포마이신 트로메타민

용도

• Susceptible infections (Investigational)
• Urinary Tract Infection (MDR E. coli)

투여 방법

가능한 부작용

• Diarrhea (most common in humans)
• Gastrointestinal upset
• Renal tubular damage / Nephrotoxicity (observed in cats)

주의사항 및 금기

• Young cats (Contraindicated due to nephrotoxicity)
• Adult cats (Relative contraindication; use with extreme caution if at all)
• > **Warning:** Appears to be highly nephrotoxic in cats, causing tubular necrosis and significant increases in serum creatinine. Use is generally contraindicated in felines. - **Renal Impairment:** In humans, renal dysfunction can substantially increase the drug's half-life and reduce urine levels. - **Dosing Strategy:** In humans, this drug is used as a one-time dose; multiple doses do not enhance efficacy and increase the incidence of adverse events. Veterinary protocols are still investigational.

약물 상호작용

• Metoclopramide: Can decrease serum concentrations and reduce urine levels of fosfomycin.
• Prokinetic agents (bethanechol, cisapride, domperidone, ranitidine, laxatives): Theoretical risk of decreasing serum and urine concentrations by increasing GI motility, similar to metoclopramide.

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