펠바메이트

용도

• Seizures (As either add-on therapy or monotherapy)
• Seizures (As a third choice antiepileptic agent)
• Seizures (For patients on phenobarb and bromides and seizure activity unchanged or having intolerable side effects)

투여 방법

가능한 부작용

• Keratoconjunctivitis sicca (KCS)
• Liver enzyme induction
• Tremor
• Limb rigidity
• Salivation
• Restlessness and agitation (at high doses)
• Blood dyscrasias (thrombocytopenia, lymphopenia, leukopenia)
• Sedation (usually when combined with other anticonvulsants)
• Vomiting/nausea (usually when combined with other anticonvulsants)

주의사항 및 금기

• Hypersensitivity to felbamate or other carbamates (e.g., meprobamate)
• > **Warning**: May cause liver enzyme induction. Half-life may decrease over time, requiring dose adjustments. * Use with caution in patients with pre-existing **hepatic dysfunction** or a history of **blood dyscrasias**. * **Pregnancy Category C**: Use only if potential benefits outweigh risks. Excreted in maternal milk, but adverse consequences to nursing puppies appear remote.

약물 상호작용

• Phenobarbital: Felbamate may increase phenobarbital levels. Phenobarbital may decrease felbamate levels.
• Phenytoin: Felbamate may increase phenytoin levels. Phenytoin may decrease felbamate levels.
• Valproate: Felbamate can cause increases in valproic acid levels.

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