디멘히드리네이트

용도

• Prevention and treatment of motion sickness/vomiting
• Prevention and treatment of motion sickness/vomiting
• Antihistamine
• Adjunctive treatment of pancreatitis
• Prevention and treatment of motion sickness (antiemetic)
• Prevention and treatment of motion sickness
• Antihistamine

투여 방법

가능한 부작용

• CNS depression (lethargy, somnolence)
• Anticholinergic effects (dry mouth, urinary retention)
• GI effects (diarrhea, vomiting, anorexia - less common)

주의사항 및 금기

• Hypersensitivity to dimenhydrinate or other antihistamines in its class
• Angle closure glaucoma (use with caution)
• Prostatic hypertrophy (use with caution)
• Pyloroduodenal or bladder neck obstruction (use with caution)
• COPD if mucosal secretions are a problem (use with caution)
• Hyperthyroidism, seizure disorders, cardiovascular disease, or hypertension (use with caution)
• > **Working Dogs**: The sedative effects of antihistamines may adversely affect the performance of working dogs. > **Allergy Testing**: Antihistamines can decrease the wheal and flare response to antigen skin testing. Discontinue at least 4 days before testing. * Tolerance to the CNS depressant effects can ensue after a few days of therapy, and antiemetic effectiveness may also diminish with prolonged use. * Safe for use during pregnancy if used cautiously (FDA Category B in humans; Papich Class B in veterinary). Small amounts are excreted in milk but are unlikely to pose much risk to nursing offspring.

약물 상호작용

• Anticholinergic drugs (e.g., tricyclic antidepressants): May potentiate the anticholinergic effects of other anticholinergic drugs.
• CNS Depressant Drugs: Increased sedation can occur if combined with other CNS depressants.
• Ototoxic Drugs (e.g., aminoglycosides): May mask the clinical signs of ototoxicity; use with caution when administering concomitantly.

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