데페록사민 메실산염

용도

• Severe iron toxicosis
• Severe iron toxicosis
• Severe iron toxicosis
• Severe iron toxicosis
• Severe iron toxicosis
• Severe iron toxicosis
• Ferric ion chelator during treatment of cardiac arrest (experimental)
• Ferric ion chelator during treatment of cardiac arrest (experimental)

투여 방법

가능한 부작용

• Allergic reactions (hives, wheezing)
• Auditory neurotoxicity (with chronic, high-dose therapy)
• Pain or swelling at injection sites
• Gastrointestinal distress
• Hypotension, tachycardia, and convulsions (if given IV too rapidly)
• Pulmonary edema (associated with rapid IV administration)

주의사항 및 금기

• Severe renal failure (unless dialysis is used to remove the ferrioxamine complex)
• > **WARNING**: Intravenous administration must be performed slowly (preferably via Constant Rate Infusion). Too rapid IV injection can precipitate severe hypotension, arrhythmias, and shock. * **Pregnancy**: FDA Category C. Has caused skeletal abnormalities in animals at doses just above those recommended for iron toxicity. Use only when benefits outweigh risks. * **Oral Use**: Oral administration is controversial and generally not recommended, as it may increase the amount of iron absorbed from the gut. * **Laboratory Interference**: May cause falsely low values on colorimetric iron assays and falsely high Total Iron Binding Capacity (TIBC) measurements.

약물 상호작용

• Prochlorperazine: Concurrent use may cause temporary impairment of consciousness.
• Vitamin C (Ascorbic Acid): May be synergistic in removing iron, but could lead to increased tissue iron toxicity, especially in cardiac muscle. Use with extreme caution in patients with preexisting cardiac disease.

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