시메티딘

용도

• All uses (gastritis, ulcers, oesophagitis, hypersecretory conditions)
• All uses (gastritis, ulcers, oesophagitis, hypersecretory conditions)

투여 방법

가능한 부작용

• Thrombocytopenia (reported in dogs)
• Transient and self-resolving slight swelling of mammary glands (female dogs)
• Hepatotoxicity (rare, reported in humans)
• Nephrotoxicity (rare, reported in humans)
• Headache (humans)
• Decreased libido (humans)

주의사항 및 금기

• No specific contraindications available, but use with caution in patients with known hypersensitivity.
• > **Warning:** Rebound gastric acid secretion may be seen on cessation of cimetidine, so therapy should be tapered. Concomitant treatment with sucralfate may be helpful. > **Warning:** If used IV, should be administered slowly over 30 minutes to prevent cardiac arrhythmias and hypotension. * Dosage should be reduced for animals with renal impairment.

약물 상호작용

• Propranolol: Increases plasma levels of beta-blockers due to CYP450 inhibition
• Verapamil: Increases plasma levels of calcium-channel blockers
• Diazepam: Increases plasma levels of diazepam
• Lidocaine: Increases plasma levels of lidocaine
• Metronidazole: Increases plasma levels of metronidazole
• Pethidine: Increases plasma levels of pethidine
• Theophylline: Increases plasma levels of theophylline
• Myelosuppressive agents: May exacerbate leucopenia
• Sucralfate: May decrease cimetidine bioavailability; administer sucralfate at least 2 hours before
• Antacids: May decrease absorption; stagger oral doses by 2 hours
• Digoxin: Altered absorption/metabolism; stagger oral doses by 2 hours
• Itraconazole: Decreased absorption of itraconazole due to reduced gastric acidity; stagger oral doses by 2 hours

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