아트라쿠륨

용도

• Neuromuscular blockade during anaesthesia
• Neuromuscular blockade during anaesthesia

투여 방법

가능한 부작용

• Histamine release (especially with rapid IV injection)
• Bronchospasm
• Hypotension
• Tachycardia
• Histamine release (especially with rapid IV administration)

주의사항 및 금기

• Conscious or inadequately anesthetized animals
• Lack of positive pressure ventilation facilities
• Lack of trained personnel to monitor neuromuscular blockade
• Conscious animals (must NEVER be administered unless the animal is adequately anesthetized)
• > **CRITICAL WARNING:** Do not administer unless the animal is adequately anaesthetized and facilities to provide positive pressure ventilation are available. * **Histamine Release:** Can precipitate the release of histamine after rapid IV administration, resulting in bronchospasm and hypotension. Diluting the drug in normal saline and giving it slowly IV minimizes these effects. * **Physiological Factors:** Hypothermia, acidosis, and hypokalaemia will prolong the duration of action of the neuromuscular blockade. * **Myasthenia Gravis:** Use the low end of the dose range in patients with myasthenia gravis. * **Monitoring:** Monitoring (using a peripheral nerve stimulator) and pharmacological reversal of the neuromuscular blockade is strongly recommended to ensure complete recovery before the end of anaesthesia.

약물 상호작용

• Volatile anaesthetics: Prolonged neuromuscular blockade
• Aminoglycosides: Prolonged neuromuscular blockade
• Clindamycin: Prolonged neuromuscular blockade
• Lincomycin: Prolonged neuromuscular blockade

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