검은과부거미 항독소

용도

• Black Widow Spider Envenomation
• Black Widow Spider Envenomation
• Black Widow Spider Envenomation
• Black Widow Spider Envenomation

투여 방법

가능한 부작용

• Anaphylaxis (incidence <2%)
• Anaphylactoid reactions (nausea, pruritus, hyperemia of the inner pinna)
• Serum sickness (delayed hypersensitivity)

주의사항 및 금기

• Known severe hypersensitivity to equine serum (relative contraindication in life-threatening envenomation)
• > **Anaphylaxis Risk:** Because this product is derived from horse serum, there is a significant risk of anaphylaxis or anaphylactoid reactions. * **Sensitivity Testing:** A 1:10 dilution given intracutaneously (0.02-0.03 mL) is suggested to test for hypersensitivity (wheal/erythema within 30 mins indicates a positive reaction). However, a negative response does not guarantee safety. * **Administration Technique:** Slow intravenous administration is usually sufficient to identify reacting animals. * **Pre-treatment:** Administering diphenhydramine prior to the antivenin is strongly recommended to sedate the patient and reduce allergic reactions. * **Reaction Management:** If an anaphylactoid reaction occurs (e.g., hyperemia of the inner pinna), stop the infusion, administer additional diphenhydramine, and restart 5 minutes later at a slower rate. * **Fluid Therapy Caution:** Use care with IV fluids, as black widow envenomation can cause significant hypertension.

약물 상호작용

• Beta-blockers: May mask the early signs associated with anaphylaxis

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