黑寡婦蜘蛛抗毒血清

用途

• Black Widow Spider Envenomation
• Black Widow Spider Envenomation
• Black Widow Spider Envenomation
• Black Widow Spider Envenomation

給藥方式

可能的副作用

• Anaphylaxis (incidence <2%)
• Anaphylactoid reactions (nausea, pruritus, hyperemia of the inner pinna)
• Serum sickness (delayed hypersensitivity)

注意事項與禁忌

• Known severe hypersensitivity to equine serum (relative contraindication in life-threatening envenomation)
• > **Anaphylaxis Risk:** Because this product is derived from horse serum, there is a significant risk of anaphylaxis or anaphylactoid reactions. * **Sensitivity Testing:** A 1:10 dilution given intracutaneously (0.02-0.03 mL) is suggested to test for hypersensitivity (wheal/erythema within 30 mins indicates a positive reaction). However, a negative response does not guarantee safety. * **Administration Technique:** Slow intravenous administration is usually sufficient to identify reacting animals. * **Pre-treatment:** Administering diphenhydramine prior to the antivenin is strongly recommended to sedate the patient and reduce allergic reactions. * **Reaction Management:** If an anaphylactoid reaction occurs (e.g., hyperemia of the inner pinna), stop the infusion, administer additional diphenhydramine, and restart 5 minutes later at a slower rate. * **Fluid Therapy Caution:** Use care with IV fluids, as black widow envenomation can cause significant hypertension.

藥物相互作用

• Beta-blockers: May mask the early signs associated with anaphylaxis

常見問題