チオグアニン

使用用途

• Acute lymphocytic and granulocytic leukemia
• Acute lymphocytic and granulocytic leukemia
• Acute myelogenous leukemias (Protocol 1 & 2)

投与方法

考えられる副作用

• Nausea
• Anorexia
• Vomiting
• Diarrhea
• Bone marrow suppression (leukopenia, thrombocytopenia, anemia)
• Hepatotoxicity
• Pancreatitis
• Gastrointestinal ulceration (including oral ulcers)
• Dermatologic reactions

注意事項と禁忌

• Hypersensitivity to thioguanine
• Pregnancy (Category D - teratogenic and mutagenic)
• > **Strict Chemotherapy Safety Precautions Apply** * **Hepatic/Renal Impairment:** Use with extreme caution; dosage adjustments may be necessary. * **Pre-existing Conditions:** Caution in patients with pre-existing bone marrow depression, active infections, or a history of urate urinary stones. * **Species Sensitivity:** Cats are highly susceptible to hematologic toxicity. * **Reproduction:** Potentially mutagenic and teratogenic. Do not use in pregnant animals. Nursing mothers should use milk replacer. * **Handling:** Personnel and owners should follow safe handling protocols for cytotoxic drugs.

薬物相互作用

• Hepatotoxic drugs (e.g., halothane, ketoconazole, valproic acid, phenobarbital, primidone): Increased risk of hepatotoxicity; use concurrently with caution.
• Immunosuppressive drugs (e.g., azathioprine, cyclophosphamide, corticosteroids): Increased risk of severe infection due to additive immunosuppression.
• Myelosuppressive drugs (e.g., chloramphenicol, flucytosine, amphotericin B, colchicine): Additive bone marrow depression; extreme caution required.
• Live vaccines: Increased risk of vaccine-induced infection or decreased vaccine efficacy; use with caution or avoid.

よくある質問