Thioguanine
別名: Tabloid, Lanvis, Tioguanina
This medication is a powerful chemotherapy drug used to treat certain types of leukemia. Because it is a potent drug, it requires careful handling and close monitoring. * **Safe Handling:** Wash your hands thoroughly after administering the medication. Do not break or crush the tablets. Pregnant women, nursing mothers, and immunocompromised individuals should avoid handling this drug or the pet's waste. * **Waste Management:** Your pet's bodily fluids (urine, feces, vomit) may contain traces of the drug for a few days after administration. Wear gloves when cleaning up accidents and wash hands afterward. * **What to Watch For:** Contact your veterinarian immediately if your pet shows signs of abnormal bleeding, bruising, severe loss of appetite, vomiting, diarrhea, yellowing of the eyes/gums (jaundice), or signs of infection (like fever or extreme lethargy). * **Appointments:** Keep all scheduled appointments for blood tests. These are mandatory to ensure the drug is not damaging your pet's bone marrow or liver.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Acute lymphocytic and granulocytic leukemia
- Acute lymphocytic and granulocytic leukemia
- Acute myelogenous leukemias (Protocol 1 & 2)
給藥方式
可能的副作用
- Nausea
- Anorexia
- Vomiting
- Diarrhea
- Bone marrow suppression (leukopenia, thrombocytopenia, anemia)
- Hepatotoxicity
- Pancreatitis
- Gastrointestinal ulceration (including oral ulcers)
- Dermatologic reactions
注意事項與禁忌
- Hypersensitivity to thioguanine
- Pregnancy (Category D - teratogenic and mutagenic)
- > **Strict Chemotherapy Safety Precautions Apply** * **Hepatic/Renal Impairment:** Use with extreme caution; dosage adjustments may be necessary. * **Pre-existing Conditions:** Caution in patients with pre-existing bone marrow depression, active infections, or a history of urate urinary stones. * **Species Sensitivity:** Cats are highly susceptible to hematologic toxicity. * **Reproduction:** Potentially mutagenic and teratogenic. Do not use in pregnant animals. Nursing mothers should use milk replacer. * **Handling:** Personnel and owners should follow safe handling protocols for cytotoxic drugs.
藥物相互作用
- Hepatotoxic drugs (e.g., halothane, ketoconazole, valproic acid, phenobarbital, primidone): Increased risk of hepatotoxicity; use concurrently with caution.
- Immunosuppressive drugs (e.g., azathioprine, cyclophosphamide, corticosteroids): Increased risk of severe infection due to additive immunosuppression.
- Myelosuppressive drugs (e.g., chloramphenicol, flucytosine, amphotericin B, colchicine): Additive bone marrow depression; extreme caution required.
- Live vaccines: Increased risk of vaccine-induced infection or decreased vaccine efficacy; use with caution or avoid.
常見問題
Thioguanine用於寵物有甚麼用途？
This medication is a powerful chemotherapy drug used to treat certain types of leukemia. Because it is a potent drug, it requires careful handling and close monitoring. * **Safe Handling:** Wash your hands thoroughly after administering the medication. Do not break or crush the tablets. Pregnant women, nursing mothers, and immunocompromised individuals should avoid handling this drug or the pet's waste. * **Waste Management:** Your pet's bodily fluids (urine, feces, vomit) may contain traces of the drug for a few days after administration. Wear gloves when cleaning up accidents and wash hands afterward. * **What to Watch For:** Contact your veterinarian immediately if your pet shows signs of abnormal bleeding, bruising, severe loss of appetite, vomiting, diarrhea, yellowing of the eyes/gums (jaundice), or signs of infection (like fever or extreme lethargy). * **Appointments:** Keep all scheduled appointments for blood tests. These are mandatory to ensure the drug is not damaging your pet's bone marrow or liver.
Thioguanine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。