ポリスチレンスルホン酸ナトリウム

使用用途

• Life-threatening hyperkalemia in neonatal foals
• Hyperkalemia
• Mild hyperkalemia (<6 mEq/L)

投与方法

考えられる副作用

• Constipation (fecal impaction reported rarely)
• Anorexia
• Vomiting
• Nausea
• Hypokalemia (from overuse)
• Hypocalcemia
• Hypomagnesemia
• Sodium retention / Hypernatremia

注意事項と禁忌

• Patients on severely restricted sodium diets
• Severe congestive heart failure (CHF)
• Severe hypertension
• Oliguric or anuric acute kidney injury (where sodium load cannot be excreted)
• Conditions predisposing to severe constipation or bowel obstruction
• Because large quantities of **sodium** may be released and absorbed during the exchange process, use with extreme caution in patients requiring sodium restriction (e.g., severe CHF, hypertension). Overdosage or prolonged use can lead to severe electrolyte derangements, specifically **hypokalemia, hypocalcemia, and hypomagnesemia**. When given orally, it is generally mixed with a cathartic (like 70% sorbitol) to hasten transit time and prevent severe constipation or fecal impaction. However, **do not use a cathartic if administering as a retention enema**, as the resin must remain in the colon for at least 30 minutes to be effective.

薬物相互作用

• Antacids (Calcium or Magnesium containing): SPS may bind with magnesium or calcium, preventing bicarbonate ion neutralization and potentially leading to systemic metabolic alkalosis. Concurrent use is not recommended.
• Laxatives (Calcium or Magnesium containing): Similar to antacids, can lead to metabolic alkalosis and reduced potassium-binding efficacy.

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