ロミフィジン

使用用途

• For sedation
• As a preanesthetic
• As an analgesic adjunct
• For epidural anesthesia for paralumbar analgesia or laparotomy
• For sedation and analgesia
• As a preanesthetic
• For sedation
• As a preanesthetic
• As an analgesic adjunct

投与方法

考えられる副作用

• Bradycardia (can be profound)
• First- and second-degree atrioventricular (AV) heart block
• Sinus arrhythmias
• Initial hypertension followed by hypotension
• Ataxia and muscle tremors
• Sweating and piloerection (horses)
• Vomiting (especially common in cats)
• Transient hyperglycemia
• Decreased gastrointestinal motility (flatulence, mild colic in horses)
• Increased urination
• Altered thermoregulation (hypothermia or hyperthermia)
• Swelling of face, lips, and upper airways; stridor (horses)
• Paradoxical excitation (rare)

注意事項と禁忌

• Known hypersensitivity to romifidine
• Concurrent use with intravenous potentiated sulfonamides
• Preexisting cardiac conditions, arrhythmias, or severe cardiovascular compromise
• Severe respiratory, hepatic, or renal disease
• Pregnancy (especially last month in horses, and throughout pregnancy in dogs/cats)
• Shock or severe systemic debilitation
• **Important Warnings:** * **Sudden Arousal**: Animals may appear deeply sedated but can still respond aggressively (e.g., kicking) to external stimuli. Use appropriate physical restraint. * **Cardiovascular Depression**: Causes significant bradycardia and AV block. Use with extreme caution in patients with preexisting heart disease. * **Vomiting Risk**: Dogs and particularly cats may vomit after administration. Fasting for at least 12 hours prior to use is recommended in small animals. * **Thermoregulation**: Can cause hypothermia during prolonged sedation; provide thermal support. * **Human Safety**: Can be absorbed through the skin and oral mucosa. Handlers should avoid self-exposure and wash immediately if accidental contact occurs.

薬物相互作用

• Intravenous Potentiated Sulfonamides (e.g., trimethoprim/sulfa): May cause fatal dysrhythmias; concurrent use is strictly contraindicated.
• Other Alpha-2 Agonists (e.g., xylazine, dexmedetomidine) & Epinephrine: Additive cardiovascular and CNS effects; epinephrine may potentiate adverse effects and arrhythmias.
• Phenothiazines (e.g., acepromazine): Can result in severe, compounding hypotension.
• Anesthetics, Opiates, Sedatives/Hypnotics: Synergistic CNS depression; significantly reduces the required dose of induction and maintenance anesthetics. Increased risk of arrhythmias with thiopental, ketamine, or halothane.

よくある質問