ロクロニウム臭化物

使用用途

• As a neuromuscular blocker
• Neuromuscular blockade / Endotracheal intubation
• As a neuromuscular blocker
• As a neuromuscular blocker
• Neuromuscular blockade during anaesthesia
• Centralize the globe for ophthalmic surgery

投与方法

考えられる副作用

• Changes in heart rate (mild, transient tachycardia)
• Changes in blood pressure (hypotension or hypertension)
• Severe anaphylaxis (reported in humans)
• Histaminoid reactions (rare)
• Severe burning pain at the injection site (if administered before deep anesthesia is achieved)
• Increased heart rate
• Mild hypertension (at high doses)

注意事項と禁忌

• Hypersensitivity to rocuronium or other neuromuscular blocking agents
• Patients who are not adequately anesthetized or sedated
• Settings lacking immediate access to intubation, mechanical ventilation, and oxygen therapy
• Conscious or inadequately anaesthetized animals
• Lack of positive pressure ventilation facilities
• Rocuronium must **only** be used by trained personnel in settings where the patient can be fully monitored and where endotracheal intubation, mechanical ventilation, oxygen therapy, and reversal agents are immediately available. It should only be administered to patients that are **adequately anesthetized or sedated**. Because the drug can cause severe burning pain upon injection, it is recommended to administer it only after a deep stage of anesthesia has been achieved. Use with caution in patients with hepatic or renal impairment, as elimination may be delayed (some sources prefer atracurium in these patients).

薬物相互作用

• Other Non-depolarizing Muscle Relaxants: May have a synergistic effect if used concurrently with rocuronium.
• Succinylcholine: May speed the onset of action and enhance the neuromuscular blocking actions of rocuronium; do not give rocuronium until succinylcholine effects have subsided.
• Aminoglycosides (e.g., gentamicin, amikacin): May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Inhalant Anesthetics (halothane, isoflurane, sevoflurane): May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Clindamycin, Lincomycin: May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Dantrolene: May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Magnesium Salts: May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Piperacillin, Mezlocillin: May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Quinidine: May enhance or prolong the neuromuscular blocking activity of rocuronium.
• Tetracyclines: May enhance or prolong the neuromuscular blocking activity of rocuronium.

よくある質問