プリマキン

使用用途

• Babesia felis
• Babesia felis
• Babesia felis

投与方法

考えられる副作用

• Vomiting (most common in cats)
• Nausea
• Myelosuppression
• Methemoglobinemia
• Hemolysis

注意事項と禁忌

• Known hypersensitivity to primaquine
• Concurrent use of bone marrow suppressant medications
• Patients susceptible to granulocytopenia (e.g., lupus, rheumatoid arthritis)
• Glucose-6-Phosphate Dehydrogenase (G-6-PD) deficiency
• Pregnancy
• Lactation
• > **WARNING**: Primaquine has an extremely narrow therapeutic index in cats. - **Dosing Confusion**: Commercially available human tablets are usually too concentrated for domestic cats. A specialized compounding pharmacy is highly recommended. Prescribers must be explicitly clear whether the dose is based on **primaquine base** or **primaquine phosphate** (26.3 mg primaquine phosphate = 15 mg primaquine base). - **G-6-PD Deficiency**: Contraindicated in humans (and theoretically animals) with Glucose-6-Phosphate Dehydrogenase deficiency due to severe risk of hemolytic anemia. - Avoid use during pregnancy and lactation due to the risk of hemolytic anemia in fetuses/nursing neonates.

薬物相互作用

• Quinacrine: May potentiate the toxicity of one another; use of primaquine within 3 months of quinacrine is not recommended.
• Bone Marrow Depressants (e.g., amphotericin B, azathioprine, chloramphenicol, antineoplastics): Concurrent use may cause an increased risk for toxicity and severe myelosuppression.
• Hemolytic Drugs (e.g., acetohydroxamic acid, sulfonylureas, quinidine, sulfonamides): Concurrent use may cause an increased risk for toxicity and hemolysis.

よくある質問