モンテルカストナトリウム

使用用途

• Feline asthma
• Adjunctive treatment of the chronic 'snuffler'
• Inflammatory Bowel Disease (IBD)
• Adjunctive treatment of feline heartworm

投与方法

考えられる副作用

• No significant adverse effects reported in cats to date
• Humans (rare): behavioral effects (aggression, suicidal thoughts), palpitations, cholestatic hepatitis, allergic granulomatous angiitis

注意事項と禁忌

• Hypersensitivity to montelukast or any component of the product
• Not for use in reversing acute bronchospasm (asthma attacks)
• **Warnings and Precautions:** * **Not a rescue medication:** Do not use to attempt to reverse acute bronchospasm or acute asthma attacks. * **Pregnancy/Nursing:** Appears safe to use during pregnancy (FDA Category B in humans). Likely safe to use during nursing, though it is excreted in milk. * **Hepatic metabolism:** Use with caution in patients with severe hepatic impairment, as the drug is extensively metabolized in the liver.

薬物相互作用

• Phenobarbital: CYP-450 enzyme inducer; may reduce montelukast plasma concentrations and efficacy.
• Rifampin: CYP-450 enzyme inducer; may reduce montelukast plasma concentrations and efficacy.
• Prednisone / Prednisolone: Severe peripheral edema has been reported in a human receiving both drugs, presumably due to increased renal tubular sodium and fluid retention. Clinical significance in veterinary patients is unclear.

よくある質問