リオチロニンナトリウム

使用用途

• Hypothyroidism
• T3 suppression test (diagnostic for hyperthyroidism)
• Hypothyroidism (unresponsive to T4)
• Hypothyroidism (refractory to T4)

投与方法

考えられる副作用

• Tachycardia
• Polyphagia
• Polyuria/Polydipsia (PU/PD)
• Excitability
• Nervousness
• Excessive panting
• Apathy or listlessness (seen in about 10% of cats)
• PU/PD (Polyuria/Polydipsia)
• Nervousness/Anxiety
• Panting
• Weight loss

注意事項と禁忌

• Acute myocardial infarction
• Thyrotoxicosis
• Untreated adrenal insufficiency
• Untreated adrenal insufficiency (Addison's disease)
• Use with extreme caution and at a lower initial dosage in patients with concurrent hypoadrenocorticism (must be treated first), cardiac disease, diabetes mellitus, or in elderly patients. Combination products containing both T3 and T4 should generally be avoided due to the risk of iatrogenic thyrotoxicosis.

薬物相互作用

• Tricyclic/Tetracyclic Antidepressants: Increased risk for CNS stimulation and cardiac arrhythmias.
• Antidiabetic Agents (insulin, oral agents): Thyroid hormones may increase the requirements for insulin or oral antidiabetic agents.
• Cholestyramine: May reduce liothyronine absorption; separate doses by at least 4 hours.
• Sympathomimetic Agents (epinephrine, norepinephrine): Thyroid hormones can potentiate the cardiovascular effects of sympathomimetics.
• Warfarin: Thyroid hormones increase the catabolism of vitamin K-dependent clotting factors, potentially increasing anticoagulation effects.
• Digoxin: Potential for reduced digoxin levels and decreased therapeutic effect.
• Ketamine: Concurrent use may cause tachycardia and hypertension.
• Sympathomimetics: Increased risk of cardiac arrhythmias and coronary insufficiency
• Insulin: May alter glucose control, requiring dosage adjustments

よくある質問