ヒドロキシウレア

使用用途

• Polycythemia vera; chronic myelogenous leukemia
• Polycythemia vera
• Polycythemia vera
• Polycythemia vera; chronic myelogenous leukemia
• Polycythemia vera
• Polycythemia vera
• Polycythemia vera
• Chronic myelogenous leukemia

投与方法

考えられる副作用

• Bone marrow depression (anemia, thrombocytopenia, leukopenia)
• GI effects (anorexia, vomiting, diarrhea)
• Stomatitis
• Sloughing of nails
• Alopecia
• Dysuria
• Pulmonary fibrosis
• Methemoglobinemia (especially in cats at high doses >500 mg)

注意事項と禁忌

• Pre-existing severe anemia or bone marrow depression
• History of urate stones
• Current severe infection
• Impaired renal function
• Patients who have recently received other chemotherapy or radiotherapy
• Pregnancy (proven teratogen)
• > **Warning**: Hydroxyurea is a known teratogen and can suppress gonadal function (arrest of spermatogenesis noted in dogs). Use only during pregnancy when benefits outweigh risks. Nursing animals should receive milk replacer. * **Myelotoxicity**: If bone marrow depression occurs, halt therapy until values return to normal. * **Feline Sensitivity**: Cats are at higher risk for bone marrow toxicity and methemoglobinemia; monitor closely.

薬物相互作用

• Bone marrow depressant drugs (e.g., chloramphenicol, flucytosine, amphotericin B, colchicine, other antineoplastics): May cause additive myelosuppression when used concurrently with hydroxyurea.
• Allopurinol: Hydroxyurea may raise serum uric acid levels; allopurinol may be required to control hyperuricemia.

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