フルルビプロフェン

使用用途

• Prevention of intraocular surgical miosis
• Ocular inflammation (uveitis)
• Prevention of intraocular surgical miosis
• Ocular inflammation (uveitis)

投与方法

考えられる副作用

• Transient ocular stinging or burning upon application
• Delayed corneal healing
• Increased risk of ocular bleeding during surgery
• Corneal melting (rare but severe)
• Transient stinging or burning upon instillation
• Ocular irritation
• Increased bleeding tendency of ocular tissues (rare)

注意事項と禁忌

• Hypersensitivity to flurbiprofen or other NSAIDs
• Active corneal ulceration (relative contraindication)
• Bleeding disorders
• Hypersensitivity to NSAIDs
• Active intraocular bleeding
• Corneal ulceration (use with extreme caution)
• Epithelial herpes simplex keratitis
• > **Warning:** May delay corneal epithelial healing. Use with extreme caution in patients with pre-existing corneal ulcers or epithelial defects. Monitor closely for signs of corneal melting or worsening ulceration. **Clinical Pearl:** Patients with a known bleeding tendency or those receiving systemic medications that prolong bleeding time should be monitored closely, as topical NSAIDs may increase bleeding of ocular tissues during surgery.

薬物相互作用

• Topical Corticosteroids: Concurrent use may increase the risk of delayed corneal healing and severe complications such as corneal melting.
• Topical Prostaglandin Analogues (e.g., Latanoprost): NSAIDs may blunt the intraocular pressure-lowering efficacy of topical prostaglandins.
• Topical prostaglandins (e.g., Latanoprost): NSAIDs may decrease the intraocular pressure-lowering efficacy of topical prostaglandin analogues.

よくある質問