デキストラン70

使用用途

• Small volume resuscitation (hypovolemic shock, head injury, pulmonary contusions, oliguric renal failure)
• Volume expansion / Augment colloid oncotic pressure
• Dehydration secondary to diarrhea (Calves)
• Small volume resuscitation (hypovolemic shock, head injury, pulmonary contusions, oliguric renal failure)
• Volume expansion / Augment colloid oncotic pressure

投与方法

考えられる副作用

• Increased bleeding times (decreased von Willebrand's factor and factor VIII activity)
• Anaphylactoid reactions (rare in dogs, but higher incidence than hetastarch)
• Acute renal failure (rare)
• Volume overload / circulatory overload
• Gastrointestinal effects (nausea, vomiting, abdominal pain - reported in humans)

注意事項と禁忌

• Preexisting severe coagulopathies
• Severe heart failure (due to risk of circulatory overload)
• Severe renal failure (oliguric/anuric, unless closely monitored)
• Intramuscular (IM) administration
• > **Critical Warnings:** > * **Circulatory Overload:** Use with extreme caution in patients susceptible to volume overload (e.g., severe cardiac or renal disease). > * **Coagulation:** Can interfere with platelet function. Use cautiously in patients with thrombocytopenia. > * **Sodium Load:** A 500 mL bag of 6% dextran 70 in normal saline contains 77 mEq of sodium. Use cautiously in patients requiring strict sodium restriction. **Laboratory Interferences:** * **Cross-matching:** May interfere with blood cross-matching by causing red blood cell cross-linking (rouleaux formation). Washing cells with isotonic saline can negate this. * **Blood Glucose:** Levels may falsely increase as dextran is degraded into glucose. * **Bilirubin:** May cause falsely elevated bilirubin levels (mechanism unknown).

よくある質問