デクスメデトミジン

使用用途

• Sedation and analgesia
• Sedation and analgesia
• Preanesthetic
• Premed prior to propofol or face mask induction (geriatric/renal/liver dysfunction)
• Slightly heavier sedation for radiographic procedures (ASA II or III)
• Minor surgery, Penn hip or OFA-types of radiographic procedures
• Surgical plane of anesthesia for OHE, castration, or abdominal surgery
• Immobilizing extremely fractious dogs and wolf-hybrid dogs
• Post-operative pain management in critically ill dogs

投与方法

考えられる副作用

• Bradycardia (profound)
• Occasional AV blocks
• Decreased respiration / Apnea
• Hypothermia
• Urination
• Vomiting
• Hyperglycemia
• Pain on injection (IM)
• Prolonged sedation
• Paradoxical excitation
• Hypersensitivity
• Pulmonary edema
• Death from circulatory failure (rare)
• Muscle tremors

注意事項と禁忌

• Cardiovascular disease
• Respiratory disorders
• Liver or kidney diseases
• Shock or severe debilitation
• Stress due to extreme heat, cold, or fatigue
• Puppies < 16 weeks (US label) or < 6 months (UK label)
• Kittens < 12 weeks (US label) or < 5 months (UK label)
• Hypersensitivity to the active substance
• > **Cardiovascular Warning:** Due to pronounced cardiovascular effects (bradycardia, vasoconstriction), only clinically healthy dogs and cats should be treated. * **Seizure Disorders:** Use with caution in animals with or prone to developing seizures; may lower the seizure threshold. * **Ocular Care:** Blinking may be impaired and tear production reduced; **eye lubricants** should be applied during sedation. * **Pregnancy/Nursing:** Not recommended for use in pregnant or breeding animals unless benefits clearly outweigh risks (FDA Category C). Safe use during nursing is not established.

薬物相互作用

• Anesthetics, Opiates, Sedative/Hypnotics: Effects may be additive; dosage reduction of one or both agents may be required. General anesthetic requirements may be reduced between 30-60%.
• Atropine, Glycopyrrolate: Can significantly increase arterial blood pressure and heart rate; use together is not recommended in dogs due to increased cardiac workload.
• Epinephrine: Possesses alpha agonist effects; do not use to treat cardiac effects caused by dexmedetomidine.
• Yohimbine: May reverse the effects, but atipamezole is preferred for clinical use.

よくある質問