アトラクリウムベシル酸塩

使用用途

• Induction dose
• Intraoperative dose
• Induction of respiratory muscle paralysis during mechanical ventilation
• Critically ill patients when low concentrations of, or no inhalant anesthesia can be used
• Intraoperative dose
• Paralysis for periophthalmic surgery (Rabbits)
• Critically ill patients when low concentrations of, or no inhalant anesthesia can be used
• Neuromuscular blockade augmentation during corneal surgery
• Muscle relaxant to facilitate intubation in patients with severe blunt trauma
• Induction of respiratory muscle paralysis during mechanical ventilation

投与方法

考えられる副作用

• Allergic reactions
• Inadequate or prolonged neuromuscular block
• Hypotension
• Vasodilation
• Bradycardia
• Tachycardia
• Dyspnea
• Bronchospasm
• Laryngospasm
• Rash
• Urticaria
• Injection site reaction

注意事項と禁忌

• Hypersensitivity to atracurium
• Relative contraindication: Myasthenia gravis
• Lack of ventilatory support (must have mechanical ventilation available)
• > **CRITICAL WARNING:** Atracurium has **NO analgesic or sedative/anesthetic actions**. Patients must be appropriately sedated/anesthetized and provided with analgesia. * **Ventilation:** Positive pressure ventilation (preferably mechanical) is absolutely required when using this drug. * **Histamine Release:** May rarely cause significant histamine release; use with caution in patients where this would be hazardous (e.g., severe cardiovascular disease, asthma). * **Myasthenia Gravis:** Use with extreme caution, or not at all, in patients suffering from myasthenia gravis. * **Vagal Tone:** Has minimal cardiac effects and will not counteract bradycardia or vagal stimulation induced by other anesthetic agents.

薬物相互作用

• Aminoglycoside antibiotics (e.g., gentamicin): May enhance the neuromuscular blocking activity of atracurium
• General anesthetics (enflurane, isoflurane, halothane, sevoflurane): May enhance and prolong the neuromuscular blocking activity
• Bacitracin, Polymyxin B (systemic): May enhance neuromuscular blocking activity
• Procainamide: May enhance neuromuscular blocking activity
• Quinidine: May enhance neuromuscular blocking activity
• Lithium: May enhance neuromuscular blocking activity
• Magnesium salts: May enhance neuromuscular blocking activity
• Anticonvulsants (Phenytoin, Carbamazepine): Reported to decrease both the effects and duration of neuromuscular blockade
• Other muscle relaxant drugs: May cause a synergistic or antagonistic effect
• Succinylcholine: May speed the onset of action and enhance the neuromuscular blocking actions of atracurium. Do not give atracurium until succinylcholine effects have diminished.

よくある質問