アレンドロン酸ナトリウム

使用用途

• Feline odontoclastic resorptive lesions (FORLs)
• Idiopathic hypercalcemia (after dietary change has been attempted)
• Refractory hypercalcemia
• Investigational treatment of histiocytic sarcoma complex

投与方法

考えられる副作用

• Upper GI irritation and erosions
• Esophageal stricture or ulceration
• Vomiting
• Inappetence
• Jaw osteonecrosis (rare but documented in humans)
• Musculoskeletal pain
• Hypocalcemia (with overdose)
• Hypophosphatemia (with overdose)

注意事項と禁忌

• Esophageal abnormalities (e.g., strictures, achalasia) that delay esophageal emptying
• Inability to stand or sit upright for 30 minutes post-administration (human guideline; veterinary relevance is managed via water chasers/activity)
• Severe renal dysfunction (Creatinine Clearance < 35 mL/min)
• Known hypersensitivity to alendronate or other bisphosphonates
• > **Esophageal Toxicity Warning:** Alendronate can cause severe local irritation to the upper gastrointestinal mucosa. * **Administration Technique:** To minimize esophageal transit time and prevent erosions, ensure the patient swallows the medication completely. In dogs, walking or playing for 30 minutes post-dose is recommended. In cats, administering at least 6 mL of water and buttering the lips to induce salivation is advised. * **Renal Impairment:** Use with extreme caution or avoid in patients with severe renal dysfunction. * **Investigational Use:** Inform owners that the use of this drug in veterinary medicine is largely investigational, and long-term safety data is lacking.

薬物相互作用

• Aspirin: Increased risk of upper GI adverse effects and erosions.
• Calcium-containing oral products or food: Likely to significantly decrease the already low oral bioavailability of alendronate.
• Ranitidine (IV): Increased oral alendronate bioavailability two-fold in a human study.
• NSAIDs: Humans taking NSAIDs with alendronate had no higher rates of GI adverse reactions than when NSAIDs were used with placebo, though caution is still advised.
• Antacids (Aluminum, Magnesium, Calcium): Significantly decreases alendronate absorption
• Iron supplements: Decreases alendronate absorption

よくある質問