阿崙膦酸鈉
別名: Fosamax, Adronat, Alendros, Arendal, Onclast
**寵物主人的重要給藥指示：** * **嚴格禁食：** 如果與食物一起服用，此藥物將不會被吸收。必須在空腹時給藥，且給藥後至少 30 分鐘內必須禁食。 * **預防食道損傷：** 如果阿崙膦酸鈉卡在食道中，可能會引起嚴重的潰瘍。 * *對於狗：* 給藥後與您的狗散步或玩耍 30 分鐘，讓牠們保持直立姿勢，確保藥丸到達胃部。 * *對於貓：* 給藥後立即用注射器餵食至少 6 毫升（約一茶匙）的水。之後在貓的嘴唇上塗抹奶油可以鼓勵吞嚥和分泌唾液，幫助藥丸安全吞下。 * **注意副作用：** 如果您的寵物出現流口水、反胃、吞嚥困難、嘔吐或食慾不振的跡象，請立即聯繫您的獸醫師。 * **試驗性使用：** 請了解此藥物在獸醫學中的使用相對較新，寵物的長期影響仍在研究中。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Feline odontoclastic resorptive lesions (FORLs)
- Idiopathic hypercalcemia (after dietary change has been attempted)
- Refractory hypercalcemia
- Investigational treatment of histiocytic sarcoma complex
給藥方式
可能的副作用
- Upper GI irritation and erosions
- Esophageal stricture or ulceration
- Vomiting
- Inappetence
- Jaw osteonecrosis (rare but documented in humans)
- Musculoskeletal pain
- Hypocalcemia (with overdose)
- Hypophosphatemia (with overdose)
注意事項與禁忌
- Esophageal abnormalities (e.g., strictures, achalasia) that delay esophageal emptying
- Inability to stand or sit upright for 30 minutes post-administration (human guideline; veterinary relevance is managed via water chasers/activity)
- Severe renal dysfunction (Creatinine Clearance < 35 mL/min)
- Known hypersensitivity to alendronate or other bisphosphonates
- > **Esophageal Toxicity Warning:** Alendronate can cause severe local irritation to the upper gastrointestinal mucosa. * **Administration Technique:** To minimize esophageal transit time and prevent erosions, ensure the patient swallows the medication completely. In dogs, walking or playing for 30 minutes post-dose is recommended. In cats, administering at least 6 mL of water and buttering the lips to induce salivation is advised. * **Renal Impairment:** Use with extreme caution or avoid in patients with severe renal dysfunction. * **Investigational Use:** Inform owners that the use of this drug in veterinary medicine is largely investigational, and long-term safety data is lacking.
藥物相互作用
- Aspirin: Increased risk of upper GI adverse effects and erosions.
- Calcium-containing oral products or food: Likely to significantly decrease the already low oral bioavailability of alendronate.
- Ranitidine (IV): Increased oral alendronate bioavailability two-fold in a human study.
- NSAIDs: Humans taking NSAIDs with alendronate had no higher rates of GI adverse reactions than when NSAIDs were used with placebo, though caution is still advised.
- Antacids (Aluminum, Magnesium, Calcium): Significantly decreases alendronate absorption
- Iron supplements: Decreases alendronate absorption
常見問題
阿崙膦酸鈉用於寵物有什麼用途？
寵物主人的重要給藥指示： • 嚴格禁食： 如果與食物一起服用，此藥物將不會被吸收。必須在空腹時給藥，且給藥後至少 30 分鐘內必須禁食。 • 預防食道損傷： 如果阿崙膦酸鈉卡在食道中，可能會引起嚴重的潰瘍。 • *對於狗：* 給藥後與您的狗散步或玩耍 30 分鐘，讓牠們保持直立姿勢，確保藥丸到達胃部。 • *對於貓：* 給藥後立即用注射器餵食至少 6 毫升（約一茶匙）的水。之後在貓的嘴唇上塗抹奶油可以鼓勵吞嚥和分泌唾液，幫助藥丸安全吞下。 • 注意副作用： 如果您的寵物出現流口水、反胃、吞嚥困難、嘔吐或食慾不振的跡象，請立即聯繫您的獸醫師。 • 試驗性使用： 請了解此藥物在獸醫學中的使用相對較新，寵物的長期影響仍在研究中。
阿崙膦酸鈉對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。