Ursodeoxycholic acid (Ursodiol)
Also known as: Ursodiol, Cholurso, Destolit, Ursofalk, Actigall
Give this medication with food to help your pet absorb it better. Do not give at the same time as antacids containing aluminum. Monitor your pet for diarrhea or worsening jaundice (yellowing of the gums or eyes). > **Contact your vet if your pet stops eating, vomits repeatedly, or becomes extremely lethargic.**
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Hepatobiliary disease / Cholestasis
- Hepatobiliary disease / Cholangitis
How it is given
Possible side effects
- Mild gastrointestinal upset (diarrhea, vomiting)
- Hepatotoxicity (rare, typically only if administered during biliary obstruction)
Cautions & contraindications
- Complete extrahepatic biliary obstruction
- Biliary fistulas
- Severe acute hepatitis
- Cholecystitis
- > **Do not use in patients with complete extrahepatic biliary obstruction.** Use with caution in patients with complications of advanced liver disease (e.g., ascites, hepatic encephalopathy).
Drug interactions
- Aluminum-based antacids: May bind to UDCA in the GI tract, decreasing its absorption and efficacy.
- Cholestyramine: Binds to UDCA, significantly decreasing its absorption.
- Colestipol: Binds to UDCA, significantly decreasing its absorption.
Frequently asked questions
What is Ursodeoxycholic acid (Ursodiol) used for in pets?
Give this medication with food to help your pet absorb it better. Do not give at the same time as antacids containing aluminum. Monitor your pet for diarrhea or worsening jaundice (yellowing of the gums or eyes). > **Contact your vet if your pet stops eating, vomits repeatedly, or becomes extremely lethargic.**
Is Ursodeoxycholic acid (Ursodiol) safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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