Sarolaner
Also known as: Simparica, Stronghold Plus, Simparica Trio
Administer the medication exactly as prescribed by your veterinarian. * **Oral tablets (Dogs):** Can be given with or without food. Ensure the dog consumes the entire dose. * **Spot-on (Cats):** Apply the liquid to the skin at the base of the neck, in front of the shoulder blades, where the cat cannot lick it off. Do not massage it in. > **Important:** Ticks and fleas must attach to your pet and start feeding to be killed by the drug. You may still see dead or dying ticks on your pet's coat. Contact your vet if your pet experiences vomiting, diarrhea, lethargy, or any uncoordinated movements.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Treatment of fleas, ticks, ear mites (Otodectes cynotis), demodicosis (Demodex canis), and Sarcoptes scabiei
- Treatment of fleas, ticks, ear mites, biting lice, adult roundworms, adult hookworms, and prevention of heartworm disease
How it is given
Possible side effects
- Mild gastrointestinal signs (vomiting, diarrhea)
- Mild pruritus or alopecia at the site of application (spot-on product)
- Neurologic signs (tremors, ataxia, seizures) - rare class effect of isoxazolines
Cautions & contraindications
- Dogs < 8 weeks of age
- Dogs < 1.3 kg body weight
- Cats < 8 weeks of age
- Cats < 1.25 kg body weight
- Known hypersensitivity to the active substance
- > **Neurologic Warning:** Use with caution in dogs and cats with a history of seizures or other neurologic disorders. Normal safety and handling precautions should be observed. Wash hands after applying topical formulations.
Drug interactions
- NSAIDs: Sarolaner is highly bound to plasma proteins and might compete with other highly bound drugs, potentially increasing free fractions.
- Warfarin: Potential competition for plasma protein binding sites.
- Milbemycin oxime: No interactions observed when co-administered.
- Moxidectin: No interactions observed when co-administered.
- Pyrantel pamoate: No interactions observed when co-administered.
Frequently asked questions
What is Sarolaner used for in pets?
Administer the medication exactly as prescribed by your veterinarian. * **Oral tablets (Dogs):** Can be given with or without food. Ensure the dog consumes the entire dose. * **Spot-on (Cats):** Apply the liquid to the skin at the base of the neck, in front of the shoulder blades, where the cat cannot lick it off. Do not massage it in. > **Important:** Ticks and fleas must attach to your pet and start feeding to be killed by the drug. You may still see dead or dying ticks on your pet's coat. Contact your vet if your pet experiences vomiting, diarrhea, lethargy, or any uncoordinated movements.
Is Sarolaner safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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