Polymyxin B
Also known as: Surolan, Polyfax
Apply exactly as directed by your veterinarian. > **Important:** Do not use in the ears if you suspect your pet's eardrum is ruptured. Stop use and contact your vet immediately if your pet shows signs of hearing loss, head tilt, loss of balance, or worsening redness/irritation at the application site. Wash hands after applying.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- External pseudomonal infections (e.g., keratoconjunctivitis, otitis externa)
- External pseudomonal infections (e.g., keratoconjunctivitis, otitis externa)
How it is given
Possible side effects
- Nephrotoxicity (if absorbed systemically)
- Ototoxicity (potential, especially if tympanic membrane is ruptured)
- Local irritation
Cautions & contraindications
- Ruptured tympanic membrane (tympanum)
- Systemic administration
- > **Do not use systemically** as it is highly nephrotoxic. > **Otic use:** Ensure the tympanic membrane is intact before application to prevent ototoxicity.
Drug interactions
- Other antibacterial agents: Acts synergistically by disrupting the outer and cytoplasmic membranes, improving penetration of other agents into bacterial cells.
- Chlorhexidine: Cationic detergents potentiate the antibacterial effects of polymyxin B against Pseudomonas aeruginosa.
- EDTA: Chelating agents potentiate the antibacterial effects of polymyxin B against Pseudomonas aeruginosa.
Frequently asked questions
What is Polymyxin B used for in pets?
Apply exactly as directed by your veterinarian. > **Important:** Do not use in the ears if you suspect your pet's eardrum is ruptured. Stop use and contact your vet immediately if your pet shows signs of hearing loss, head tilt, loss of balance, or worsening redness/irritation at the application site. Wash hands after applying.
Is Polymyxin B safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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