Oclacitinib
Also known as: Apoquel
Oclacitinib (Apoquel) is a fast-acting medication used to stop your dog's itching and reduce skin inflammation. * **Administration:** Can be given with or without food. If vomiting occurs, try giving it with a small meal. * **What to watch for:** Monitor your dog for vomiting, diarrhea, or lethargy. Because this drug changes how the immune system responds, watch closely for signs of new infections (like ear infections, skin bumps, or coughing) and report them to your vet. * **Lumps and bumps:** Check your dog's skin regularly for any new lumps or warts and point them out at your next vet visit. * **Do not use in:** Puppies under 1 year of age, or pregnant/nursing dogs. * **Handling:** Wash your hands after handling the tablets.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
How it is given
Possible side effects
- Gastrointestinal upset (vomiting, diarrhea, anorexia)
- Lethargy
- Increased susceptibility to infections (e.g., pyoderma, otitis, demodicosis, pneumonia)
- Transient decreases in leukocytes and serum globulins
- Potential exacerbation of neoplastic conditions
- Histiocytomas or papillomas (benign skin masses)
Cautions & contraindications
- Dogs less than 12 months of age
- Dogs weighing less than 3 kg
- Dogs with severe systemic infections
- Breeding, pregnant, or lactating dogs
- Dogs with evidence of immune suppression (e.g., hyperadrenocorticism)
- Dogs with a history of progressive malignant neoplasia
- Use with caution in dogs with a history of recurrent infections or neoplasia. **Routine monitoring** for the development of infections (skin, ears, systemic) and abnormal growths is essential. > **Note:** Oclacitinib is not approved for use in cats, and its safety and efficacy profile in felines is not fully established, though it is sometimes used off-label by dermatologists.
Drug interactions
- Corticosteroids: Increased risk of immunosuppression and secondary infections.
- Cyclosporine: Increased risk of profound immunosuppression.
- Modified live vaccines: Potential for decreased vaccine efficacy or vaccine-induced illness due to immunomodulation.
Frequently asked questions
What is Oclacitinib used for in pets?
Oclacitinib (Apoquel) is a fast-acting medication used to stop your dog's itching and reduce skin inflammation. * **Administration:** Can be given with or without food. If vomiting occurs, try giving it with a small meal. * **What to watch for:** Monitor your dog for vomiting, diarrhea, or lethargy. Because this drug changes how the immune system responds, watch closely for signs of new infections (like ear infections, skin bumps, or coughing) and report them to your vet. * **Lumps and bumps:** Check your dog's skin regularly for any new lumps or warts and point them out at your next vet visit. * **Do not use in:** Puppies under 1 year of age, or pregnant/nursing dogs. * **Handling:** Wash your hands after handling the tablets.
Is Oclacitinib safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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