Mycobacterial Cell Wall Fraction Immunomodulator
Also known as: Regressin-V, Equimune I.V., Settle
- **Injection Site Reactions:** Intratumoral injection may cause pain or tenderness at the injection site. - **Tumor Changes:** Tumors may drain or become necrotic (tissue death). > **Note:** This indicates the treatment is working! If this occurs and is bothersome, contact your veterinarian for further instructions on management. - **Systemic Signs:** Treated animals may be depressed, develop a fever, or have a reduced appetite for a few days after treatment. If these persist beyond 1-2 days or are severe, contact your veterinarian.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
Veterinary professional? See the full dosing-by-species reference on VetSheet →
What it is used for
- Immunotherapy of sarcoids
- Immunotherapeutic agent for the treatment of Equine Respiratory Disease Complex (ERDC)
- Aid in the treatment of equine metritis caused by Streptococcus zooepidemicus
- Aid in the treatment of equine metritis caused by Streptococcus zooepidemicus
- Immunotherapy of mixed mammary tumor and mammary adenocarcinoma
How it is given
Possible side effects
- Transient fever
- Depression or drowsiness
- Decreased appetite
- Localized pain and tenderness at injection site
- Tumor necrosis and draining (expected therapeutic effect but can be an adverse event)
- Hypersensitivity or Anaphylaxis
- Severe respiratory inflammatory reactions (reported in horses)
Cautions & contraindications
- Prior hypersensitivity to mycobacterial cell wall compounds
- Active mycobacterial infections
- Patients receiving cortisone or ACTH may not respond to treatment due to immunosuppression. In case of an anaphylactic reaction, administer epinephrine. The emulsion separates rapidly and must be thoroughly mixed/re-emulsified immediately before administration.
Drug interactions
- Corticosteroids, ACTH, Immunosuppressive drugs (e.g., cyclosporine): May reduce the effectiveness of mycobacterial cell wall immunostimulants
Frequently asked questions
What is Mycobacterial Cell Wall Fraction Immunomodulator used for in pets?
- Injection Site Reactions: Intratumoral injection may cause pain or tenderness at the injection site. - Tumor Changes: Tumors may drain or become necrotic (tissue death). > Note: This indicates the treatment is working! If this occurs and is bothersome, contact your veterinarian for further instructions on management. - Systemic Signs: Treated animals may be depressed, develop a fever, or have a reduced appetite for a few days after treatment. If these persist beyond 1-2 days or are severe, contact your veterinarian.
Is Mycobacterial Cell Wall Fraction Immunomodulator safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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