Mibolerone
Also known as: Cheque Drops
* **Strict Compliance:** Give this medication exactly as prescribed. Missing doses can result in treatment failure (e.g., the dog coming into heat). * **Behavioral Changes:** You may notice changes such as increased mounting/riding behavior, voice deepening, or increased body odor. * **Physical Changes:** Mild enlargement of the clitoris or vaginal discharge may occur. Contact your veterinarian if these become severe. * **Handling Precautions:** Because this is an anabolic steroid, wear gloves when handling the medication, especially if you are pregnant. > **Do not give to cats!** This medication is highly toxic and potentially fatal to cats.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Suppression of estrus
- Pseudocyesis (false pregnancy)
- Pseudocyesis (false pregnancy)
- Cystic endometrial hyperplasia (CEH)
- Treatment of severe galactorrhea
How it is given
Possible side effects
- Premature epiphyseal closure (in prepuberal females)
- Clitoral enlargement / hypertrophy
- Vaginitis / Vulvovaginitis
- Increased body odor
- Abnormal behavior (e.g., riding/mounting behavior)
- Urinary incontinence
- Voice deepening
- Enhanced clinical signs of seborrhea oleosa
- Epiphora (tearing)
- Hepatic changes (intranuclear hyaline bodies) and rare hepatic dysfunction
- Increased kidney weight
- Fatalities, thyroid dysfunction, and pancreatic dysfunction (in cats)
Cautions & contraindications
- Perianal adenoma or perianal adenocarcinoma
- Other androgen-dependent neoplasias
- Pregnant or lactating bitches
- Patients with ongoing or a history of liver or kidney disease
- Bedlington Terriers
- Cats
- Mibolerone should not be used in pregnant bitches as **masculinization of female fetuses** will occur (changes in vagina patency, phallus-like structure, testes-like structures). It inhibits lactation and should not be used in nursing bitches. The manufacturer recommends discontinuing the product after 24 months of use. Do not use to abbreviate an estrous period or in bitches prior to their first estrous period. **Extremely toxic to cats.**
Drug interactions
- Phenytoin: Increased seizure activity has been reported in a dog previously controlled on phenytoin.
- Progestins: Should generally not be used concurrently.
- Estrogens: Should generally not be used concurrently.
Frequently asked questions
What is Mibolerone used for in pets?
* **Strict Compliance:** Give this medication exactly as prescribed. Missing doses can result in treatment failure (e.g., the dog coming into heat). * **Behavioral Changes:** You may notice changes such as increased mounting/riding behavior, voice deepening, or increased body odor. * **Physical Changes:** Mild enlargement of the clitoris or vaginal discharge may occur. Contact your veterinarian if these become severe. * **Handling Precautions:** Because this is an anabolic steroid, wear gloves when handling the medication, especially if you are pregnant. > **Do not give to cats!** This medication is highly toxic and potentially fatal to cats.
Is Mibolerone safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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