Grapiprant

What it is used for

• Management of mild to moderate pain caused by osteoarthritis

How it is given

Possible side effects

• Vomiting
• Diarrhea
• Anorexia
• Lethargy
• Decreased serum albumin
• Soft-formed faeces
• Diarrhoea
• Inappetence
• Mild decreases in serum albumin and total protein
• Haematemesis (very rare)
• Haemorrhagic diarrhoea (very rare)

Cautions & contraindications

• Hypersensitivity to grapiprant
• Concurrent use with other NSAIDs or corticosteroids
• Breeding, pregnant, or lactating dogs
• Dogs under 9 months of age or weighing less than 3.6 kg
• Dogs under 9 months of age
• Dogs weighing less than 3.6 kg
• Cats (not authorized for use)
• Known hypersensitivity to grapiprant
• Use with caution in dogs with pre-existing **hepatic** or **renal** disease, or those with a history of **gastrointestinal** disease. Monitor liver enzymes, kidney values, and clinical signs of GI upset. > **Clinical Pearl:** Although COX-sparing, gastrointestinal adverse effects (vomiting, diarrhea) remain the most commonly reported side effects in clinical practice.

Drug interactions

• Other NSAIDs: Increased risk of gastrointestinal toxicity
• Corticosteroids: Increased risk of gastrointestinal ulceration
• Highly protein-bound drugs: Potential competition for protein binding sites
• Other NSAIDs (e.g., meloxicam, carprofen): Increased risk of gastrointestinal toxicity and adverse effects. Concurrent use should be avoided.
• Corticosteroids (e.g., prednisolone, dexamethasone): Increased risk of gastrointestinal ulceration and adverse effects. Concurrent use should be avoided.

Frequently asked questions