Diphenoxylate
Also known as: Co-phenotrope, Lofenoxal, Lomotil
Diphenoxylate is used to treat severe diarrhea by slowing down gut movement. * **Do not give more than prescribed**, as overdosing can cause serious side effects including extreme sleepiness and constipation. * Ensure your pet has access to plenty of fresh water to prevent dehydration. * Contact your veterinarian if the diarrhea persists for more than 48 hours, if your pet becomes lethargic, or if you notice blood in the stool.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
How it is given
Possible side effects
- Constipation
- Sedation
- Bloating
- Paralytic ileus
- CNS depression (especially in cats)
- Anticholinergic effects at high doses (dry mouth, tachycardia)
Cautions & contraindications
- Toxigenic diarrhea
- Infectious enteritis (e.g., Salmonella, Parvovirus)
- Obstructive GI disease
- Severe liver disease
- Cats (generally avoided due to CNS excitation/depression)
- > **Caution:** Do not use in cases of infectious diarrhea where pathogen clearance is necessary. Use with extreme caution in cats due to increased sensitivity to opioids. Monitor for signs of ileus or severe constipation.
Drug interactions
- Monoamine Oxidase Inhibitors (MAOIs): May cause severe hypertensive crisis
- CNS Depressants (e.g., sedatives, anesthetics): Additive CNS and respiratory depression
- Anticholinergics: Additive anticholinergic effects and increased risk of severe ileus
Frequently asked questions
What is Diphenoxylate used for in pets?
Diphenoxylate is used to treat severe diarrhea by slowing down gut movement. * **Do not give more than prescribed**, as overdosing can cause serious side effects including extreme sleepiness and constipation. * Ensure your pet has access to plenty of fresh water to prevent dehydration. * Contact your veterinarian if the diarrhea persists for more than 48 hours, if your pet becomes lethargic, or if you notice blood in the stool.
Is Diphenoxylate safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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